1-(3-Propyloxiran-2-yl)pyrrolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3-Propyloxiran-2-yl)pyrrolidine
• 英文别名: 1-(3-propyloxiran-2-yl)pyrrolidine
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: RGEUTPZGXOQOIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR MODULER LA TYROSINE KINASE DE BRUTON
  申请人：CORVUS PHARMACEUTICALS INC

  公开号：WO2017156495A1

  公开（公告）日：2017-09-14

  Provided herein, inter alia, are compounds and methods for modulating Bruton's Tyrosine Kinase.
• [EN] SULFONAMIDE SUBSTITUTED N-(1H-INDOL-7-YL) BENZENESULFONAMIDES AND USES THEREOF<br/>[FR] N-(1H-INDOL-7-YL)BENZÈNESULFONAMIDES À SUBSTITUTION SULFONAMIDE ET LEURS UTILISATIONS
  申请人：[en]TRIANA BIOMEDICINES, INC.

  公开号：WO2022169755A1

  公开（公告）日：2022-08-11

  The present application discloses novel compounds of formula (I), pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a compound of the disclosure. Methods of treating disease and disorders that results from abnormal activity of a target protein in a subject, are also disclosed.