N-(5-Chloro-4-diazo-2-methylcyclohexa-2,5-dien-1-ylidene)benzamide--hydrogen chloride (1/1) | 119529-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-Chloro-4-diazo-2-methylcyclohexa-2,5-dien-1-ylidene)benzamide--hydrogen chloride (1/1)
• 英文别名: N-(5-chloro-4-diazo-2-methylcyclohexa-2,5-dien-1-ylidene)benzamide;hydrochloride
• CAS: 119529-48-5
• 化学式: C14H11Cl2N3O
• 分子量: 308.2
• InChiKey: WTNHNWIPTMEJCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.39
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Drug eluting device for treating vascular diseases
  申请人：——

  公开号：US20020119178A1

  公开（公告）日：2002-08-29

  The present invention relates to a device and method for delivering locally therapeutic agents within adjacent tissues such as an arterial wall for treating vascular diseases. The device comprises i) an endovascular device, ii) an hydrophobic linker molecule containing a diazonium moiety electrodeposited onto the surface of the endovascular device, and iii) a lipophilic drug passively deposited on the linker molecule, said drug binding to the linker molecule through hydrophobic interactions for elution from the endovascular device over time. The present invention also relates to a method for preparing such device.

  本发明涉及一种在邻近组织（如动脉壁）内局部递送治疗剂以治疗血管疾病的装置和方法。该装置包括 i) 血管内装置；ii) 电沉积在血管内装置表面的含有重氮分子的疏水连接分子；iii) 被动沉积在连接分子上的亲脂药物，所述药物通过疏水相互作用与连接分子结合，随着时间的推移从血管内装置中洗脱出来。本发明还涉及制备这种装置的方法。
• [EN] DRUG ELUTING DEVICE FOR TREATING VASCULAR DISEASES<br/>[FR] DISPOSITIF DE DIFFUSION DE MEDICAMENTS PAR ELUTION POUR LE TRAITEMENT DE TROUBLES VASCULAIRES
  申请人：ANGIOGENE INC

  公开号：WO2002066092A2

  公开（公告）日：2002-08-29

  The present invention relates to a device and method for delivering locally therapeutic agents within adjacent tissues such as an arterial wall for treating vascular diseases. The device comprises i) an endovascular device, ii) an hydrophobic linker molecule containing a diazonium moiety electrodeposited onto the surface of the endovascular device, and iii) a lipophilic drug passively deposited on the linker molecule, said drug binding to the linker molecule through hydrophobic interactions for elution from the endovascular device over time. The present invention also relates to a method for preparing such device.