N-cyclohexyl-N-(4-butenyl)amine | 61907-83-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-cyclohexyl-N-(4-butenyl)amine
• 英文别名: Cyclohexanamine, N-3-butenyl-；N-but-3-enylcyclohexanamine
• CAS: 61907-83-3
• 化学式: C₁₀H₁₉N
• 分子量: 153.268
• InChiKey: HTKLBKAOCCPEJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-cyclohexyl-N-(4-butenyl)amine 以 四氢呋喃 为溶剂， 反应 18.5h， 生成 pentacarbonyl[(N-cyclohexyl-N-(3-buten-1-yl)amino)methylene]chromium(0)
  参考文献：
  名称：

  N-Heterocycles from Chromium Aminocarbenes

  摘要：

  The initial [2 + 2]-cycloadduct between a chromium aminocarbene and a tethered alkene undergoes a beta-hydrogen elimination very efficiently when triphenylphosphine is added as a ligand. The reaction gives cyclic enamines or homoenamines depending on the substitution on the alkene.

  DOI：

  10.1021/acs.orglett.5b00313
• 作为产物：
  描述：

  六氢-1,3,5-三环己基-S-三嗪 在 盐酸 、 甲基锂 作用下， 以 乙醚 为溶剂， 生成 N-cyclohexyl-N-(4-butenyl)amine
  参考文献：
  名称：

  经由N-烷基-N-（烷基硫代甲基）氯化铵使脂族伯胺单烷基化。形成稳定的N-亚甲基烷基胺的证据

  摘要：

  单体Ñ -methylenealkylamines（3），从形成ñ -烷基- ñ - （烷基硫代）氯化铵（5）是在-60℃下稳定，并且可以与有机金属试剂被捕获，以提供Ñ，Ñ -dialkylamines（8）。

  DOI：

  10.1039/c39840000427

文献信息

• NOVEL DERIVATIVES OF BENZIMIDAZOLE AND IMIDAZO-PYRIDINE AND THEIR USE AS MEDICAMENTS
  申请人：POITOUT Lydie

  公开号：US20090270372A1

  公开（公告）日：2009-10-29

  A subject of the present Application is novel derivatives of benzimidazole and imidazopyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.

  本申请的主题是苯并咪唑和咪唑吡啶的新衍生物，它们对于某些亚型的黑色素皮质素受体，特别是MC4受体具有良好的亲和力。它们特别适用于治疗涉及一个或多个黑色素皮质素受体的病理条件和疾病。本发明还涉及含有上述产物的制药组合物。
• Novel derivatives of benzimidazale and imidazo-pyridine and their use as medicaments
  申请人：Poitout Lydie

  公开号：US20080139619A1

  公开（公告）日：2008-06-12

  A subject of the present application is novel derivatives of benzimidazole and imidazo-pyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.

  本申请的主题是苯并咪唑和咪唑吡啶的新衍生物，它们对于某些亚型的黑素皮质素受体，特别是MC4受体具有良好的亲和力。它们特别适用于治疗涉及一个或多个黑素皮质素受体的病理条件和疾病。本发明还涉及含有上述产品的制药组合物。
• BARLUENGA, J.;BAYON, A. M.;ASENSIO, G., J. CHEM. SOC. CHEM. COMMUN., 1984, N 7, 427-428
  作者：BARLUENGA, J.、BAYON, A. M.、ASENSIO, G.

  DOI：——

  日期：——
• PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS
  申请人：Alcon Inc.

  公开号：US20210284806A1

  公开（公告）日：2021-09-16

  The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a photochromic contact lens from a polymerizable composition comprising at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.
• US7501525B2
  申请人：——

  公开号：US7501525B2

  公开（公告）日：2009-03-10