N,N-dimethyl-1-(4-pyridin-2-ylphenyl)methanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N-dimethyl-1-(4-pyridin-2-ylphenyl)methanamine
• 化学式: C₁₄H₁₆N₂
• 分子量: 212.29
• InChiKey: DEEOQYMOCQNCGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PURINE DERIVATIVES AS DRUGS FOR THE TREATMENT OF NEONATAL HYPOXIA-ISCHEMIA BRAIN INJURY AND RELATED DISEASES<br/>[FR] DÉRIVÉS DE PURINE EN TANT QUE MÉDICAMENTS POUR LE TRAITEMENT D'UNE LÉSION CÉRÉBRALE HYPOXIQUE-ISCHÉMIQUE NÉONATALE ET DE MALADIES ASSOCIÉES
  申请人：COMMISSARIAT ENERGIE ATOMIQUE

  公开号：WO2021214315A1

  公开（公告）日：2021-10-28

  The present invention relates to a compound of formula (I), for use in the treatment of non-traumatic acquired brain injury, in which M represents a NR1R2 group, an OR1 group or a SR1 group, A represents a NR4R5 group, an OR10 group or a hydrogen atom, R3 is a (C1-C6)alkyl group, a (C1-C6)cycloalkyl group, an aryl group, a -CH2-aryl group, a CH2-(C1-C6)cycloalkyl group or a -CH2-heteroaryl group, and its addition salts with pharmaceutically acceptable acids. The present invention further relates to a compound of formula (I) wherein R5 is a (C1-C8)alkyl group or a (C1-C6)cycloalkyl group, said alkyl and cycloalkyl group being substituted with one, two or three -OCORa group(s).

  本发明涉及一种具有式（I）的化合物，用于治疗非创伤性获得性脑损伤，其中M代表NR1R2基团、OR1基团或SR1基团，A代表NR4R5基团、OR10基团或氢原子，R3是（C1-C6）烷基基团、（C1-C6）环烷基基团、芳基、-CH2-芳基、CH2-(C1-C6)环烷基基团或-CH2-杂芳基，以及其与药学上可接受的酸形成的加合盐。本发明还涉及式（I）中R5为（C1-C8）烷基基团或（C1-C6）环烷基基团的化合物，所述烷基和环烷基基团被一个、两个或三个-OCORa基团取代。
• Purine derivatives as tools for screening anti-Alzheimer compounds
  申请人：Manros Therapeutics

  公开号：EP2664619B1

  公开（公告）日：2017-07-12