(2E)-2-(5-hydroxy-5,7,8,9-tetrahydrobenzo[7]annulen-6-ylidene)acetic acid | 326809-98-7

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: (2E)-2-(5-hydroxy-5,7,8,9-tetrahydrobenzo[7]annulen-6-ylidene)acetic acid
• CAS: 326809-98-7
• 化学式: C₁₃H₁₄O₃
• 分子量: 218.25
• InChiKey: UADPGHINQMWEAG-CSKARUKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT OF ACUTE BRAIN INJURY<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'UNE LÉSION CÉRÉBRALE AIGUË
  申请人：UNIV COPENHAGEN

  公开号：WO2019149329A1

  公开（公告）日：2019-08-08

  The invention relates to a compound according to formula I wherein when R5 is H, and R1 and R2 form a ring system, then said compound is selected from the following compounds of formula II or formula IV or when R2 is H, and R1 and R5 form a ring system, then said compound has formula III

  该发明涉及一种化合物，其符合以下公式I，其中当R5为H时，并且R1和R2形成一个环系统时，所述化合物选自以下公式II或公式IV的化合物，或者当R2为H时，并且R1和R5形成一个环系统时，所述化合物具有公式III。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Devices and methods for facilitating and controlling use of a medication
  申请人：JAZZ PHARMACEUTICALS, INC.

  公开号：US11033530B2

  公开（公告）日：2021-06-15

  A device includes a reservoir configured to store a drug formulation including at least one abuse-preventing additive. The device further includes means configured to remove the at least one abuse-preventing additive. The device further includes means configured to prevent access to the drug formulation.

  一种装置包括一个储存器，配置用于储存包括至少一种防止滥用添加剂的药物制剂。该装置还包括用于移除至少一种防止滥用添加剂的装置。该装置还包括用于防止接触药物制剂的装置。
• DEVICES AND METHODS FOR FACILITATING AND CONTROLLING USE OF A MEDICATION
  申请人：JAZZ PHARMACEUTICALS, INC.

  公开号：US20150202588A1

  公开（公告）日：2015-07-23

  A device includes a reservoir configured to store a drug formulation including at least one abuse-preventing additive. The device further includes means configured to remove the at least one abuse-preventing additive. The device further includes means configured to prevent access to the drug formulation.
• COMPOSITIONS AND METHODS FOR TREATING SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY (SSADHD)
  申请人：WASHINGTON STATE UNIVERSITY

  公开号：US20210008225A1

  公开（公告）日：2021-01-14

  Provided herein are compositions and methods for treating succinic semialdehyde dehydrogenase deficiency (SSADHD). Compositions may include a gene encoding a functional succinic semialdehyde dehydrogenase (SSADH) enzyme, such as ALDH5A1, operably linked to a targeting vector. The functional SSADH enzyme is envisioned to lower the levels of circulating gamma-hydroxybutyric acid (GHB) and γ-aminobutyric acid (GABA). In some embodiments, combination therapies are envisioned, comprising administering to the subject therapeutically effective amounts of a combination of a composition comprising a gene encoding a functional SSADH enzyme operably linked to a targeting vector; one or more mTOR inhibitors; and a GABA-T inhibitor. Suitable mTOR inhibitors include rapamycin, while suitable GABA-T inhibitors include vigabatrin.