N-(4-(trifluoromethyl)phenyl)quinazolin-4-amine | 849589-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(4-(trifluoromethyl)phenyl)quinazolin-4-amine
• 英文别名: N-[4-(trifluoromethyl)phenyl]quinazolin-4-amine
• CAS: 849589-40-8
• 化学式: C₁₅H₁₀F₃N₃
• 分子量: 289.26
• InChiKey: XPRLZMLSEYAJNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(4-(trifluoromethyl)phenyl)quinazolin-4-amine 、 二苯基乙炔 在 四丁基溴化铵 、 copper diacetate 、 palladium diacetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以62%的产率得到4-(2,3-diphenyl-5-(trifluoromethyl)-1H-indol-1-yl)quinazoline
  参考文献：
  名称：

  Catalyst and solvent switched divergent C–H functionalization: oxidative annulation of N-aryl substituted quinazolin-4-amine with alkynes

  摘要：

  催化剂和溶剂控制的N-芳基取代的喹唑啉-4-胺与内部炔烃的C-H键的ortho/peri位选择性氧化环化。

  DOI：

  10.1039/d0ob00318b
• 作为产物：
  描述：

  2-氨基苯甲腈 在 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 N-(4-(trifluoromethyl)phenyl)quinazolin-4-amine
  参考文献：
  名称：

  Catalyst and solvent switched divergent C–H functionalization: oxidative annulation of N-aryl substituted quinazolin-4-amine with alkynes

  摘要：

  催化剂和溶剂控制的N-芳基取代的喹唑啉-4-胺与内部炔烃的C-H键的ortho/peri位选择性氧化环化。

  DOI：

  10.1039/d0ob00318b

文献信息

• QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF HERPESVIRAL INFECTIONS
  申请人：GPC Biotech AG

  公开号：EP1673346A1

  公开（公告）日：2006-06-28
• Quinazoline derivatives for the treatment of herpesviral infections
  申请人：Herget Thomas

  公开号：US20070123537A1

  公开（公告）日：2007-05-31

  The present invention relates to phenyl-quinazolinyl-amine derivatives and pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising at least one of these derivatives and/or pharmaceutically salts thereof, as well as the use of these derivatives for the prophylaxis and/or treatment of herpesviral induced infections, including opportunistic infections, especially for the prophylaxis and/or treatment of infections and diseases induced by HCMV.
• [EN] QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF HERPESVIRAL INFECTIONS<br/>[FR] DERIVES DE QUINAZOLINE POUR LE TRAITEMENT D'INFECTIONS VIRALES HERPETIQUES
  申请人：AXXIMA PHARMACEUTICALS AG

  公开号：WO2005040125A1

  公开（公告）日：2005-05-06

  The present invention relates to phenyl-quinazolinyl-amine derivatives and pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising at least one of these derivatives and/or pharmaceutically salts thereof, as well as the use of these derivatives for the prophylaxis and/or treatment of herpesviral induced infections, including opportunistic infections, especially for the prophylaxis and/or treatment of infections and diseases induced by HCMV.
• Catalyst and solvent switched divergent C–H functionalization: oxidative annulation of <i>N</i>-aryl substituted quinazolin-4-amine with alkynes
  作者：Siddi Ramulu Meesa、Praveen Kumar Naikawadi、Kishan Gugulothu、K. Shiva Kumar

  DOI：10.1039/d0ob00318b

  日期：——

  Catalyst and solvent controlled ortho/peri site-selective oxidative annulation of C–H bonds of N-aryl substituted quinazolin-4-amines with internal alkynes.

  催化剂和溶剂控制的N-芳基取代的喹唑啉-4-胺与内部炔烃的C-H键的ortho/peri位选择性氧化环化。