Methyl 3-[4-[3-(1-adamantyl)-5-[(1,3-dioxoisoindol-2-yl)methyl]-4-hydroxyphenyl]phenyl]prop-2-enoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3-[4-[3-(1-adamantyl)-5-[(1,3-dioxoisoindol-2-yl)methyl]-4-hydroxyphenyl]phenyl]prop-2-enoate
• 英文别名: methyl 3-[4-[3-(1-adamantyl)-5-[(1,3-dioxoisoindol-2-yl)methyl]-4-hydroxyphenyl]phenyl]prop-2-enoate
• 化学式: C₃₅H₃₃NO₅
• 分子量: 547.6
• InChiKey: KIMHUQLBOGSNPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities
  申请人：——

  公开号：US20040235757A1

  公开（公告）日：2004-11-25

  Are described compounds of Formula (I) in which R, R′, R″, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterised by altered angiogenesis and as antitumorals.

  化合物的公式（I）中的R，R'，R''，A和D的含义如文本所述，可用作治疗具有改变的血管生成的病理特征和抗肿瘤剂的有用药剂。
• Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities
  申请人：Dallavalle Sabrina

  公开号：US20080021088A1

  公开（公告）日：2008-01-24

  Described and claimed are compounds of Formula (I) in which R, R′, R″, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.

  描述和声明的是化合物式（I）的化合物，其中R、R'、R"、A和D在文本中所描述的含义，作为治疗由异常血管生成特征的病理状况和抗肿瘤剂的有用药物。
• RETINOID DERIVATIVES WITH ANTIANGIOGENIC, ANTITUMOR AND PROAPOPTOTIC ACTIVITIES
  申请人：SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP1412317B1

  公开（公告）日：2010-12-22
• COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT
  申请人：SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP2101820A2

  公开（公告）日：2009-09-23
• US7449495B2
  申请人：——

  公开号：US7449495B2

  公开（公告）日：2008-11-11