4-Hydrazino-5-methyl-2-methylthio-pyrimidin | 30150-44-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-Hydrazino-5-methyl-2-methylthio-pyrimidin
• 英文别名: 4-hydrazino-5-methyl-2-methylsulfanyl-pyrimidine；(5-Methyl-2-methylsulfanylpyrimidin-4-yl)hydrazine
• CAS: 30150-44-8
• 化学式: C₆H₁₀N₄S
• mdl: MFCD19201629
• 分子量: 170.238
• InChiKey: QPBOKAFYLNLUQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  89.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  溴化氰 、 4-Hydrazino-5-methyl-2-methylthio-pyrimidin 以 二氯甲烷 、 异丙醇 为溶剂， 以95%的产率得到3-amino-8-methyl-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine hydrobromide
  参考文献：
  名称：

  Penoxsulam—Structure–activity relationships of triazolopyrimidine sulfonamides

  摘要：

  The discovery of the sulfonamide herbicides, which inhibit the enzyme acetolactate synthase (ALS), has resulted in many investigations to exploit their herbicidal activity. One area which proved particularly productive was the N-aryltriazolo[1,5-c]pyrimidine sulfonamides, providing three commercial herbicides, cloransulam-methyl, diclosulam and florasulam. Additional structure-activity investigations by reversing the sulfonamide linkage resulted in the discovery of triazolopyrimidine sulfonamides with cereal crop selectivity and high levels of grass and broadleaf weed control. Research efforts to exploit these high levels of weed activity ultimately led to the discovery of penoxsulam, a new herbicide developed for grass, sedge and broadleaf weed control in rice. Synthetic efforts and structure-activity relationships leading to the discovery of penoxsulam will be discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.02.010

文献信息

• TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF
  申请人：CHAN Ho Man

  公开号：US20160176882A1

  公开（公告）日：2016-06-23

  A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R 1 , R 2 , R 3 , R 4 , R 5 , and n are as defined herein.

  提供了一种由化合物（I）或其药学上可接受的盐组成的药物，已被证明对治疗PRC2介导的疾病或紊乱有用：其中R1、R2、R3、R4、R5和n的定义如本文所述。
• US9580437B2
  申请人：——

  公开号：US9580437B2

  公开（公告）日：2017-02-28
• Penoxsulam—Structure–activity relationships of triazolopyrimidine sulfonamides
  作者：Timothy C. Johnson、Timothy P. Martin、Richard K. Mann、Mark A. Pobanz

  DOI：10.1016/j.bmc.2009.02.010

  日期：2009.6

  The discovery of the sulfonamide herbicides, which inhibit the enzyme acetolactate synthase (ALS), has resulted in many investigations to exploit their herbicidal activity. One area which proved particularly productive was the N-aryltriazolo[1,5-c]pyrimidine sulfonamides, providing three commercial herbicides, cloransulam-methyl, diclosulam and florasulam. Additional structure-activity investigations by reversing the sulfonamide linkage resulted in the discovery of triazolopyrimidine sulfonamides with cereal crop selectivity and high levels of grass and broadleaf weed control. Research efforts to exploit these high levels of weed activity ultimately led to the discovery of penoxsulam, a new herbicide developed for grass, sedge and broadleaf weed control in rice. Synthetic efforts and structure-activity relationships leading to the discovery of penoxsulam will be discussed. (C) 2009 Elsevier Ltd. All rights reserved.