4-amino-N-[2-(2,2-dimethylpropanoyl)-1H-indol-5-yl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-N-[2-(2,2-dimethylpropanoyl)-1H-indol-5-yl]benzamide
• 化学式: C₂₀H₂₁N₃O₂
• 分子量: 335.4
• InChiKey: XFKYYRURIFHPGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  88
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Conjugates of CC-1065 analogs and bifunctional linkers
  申请人：SYNTARGA BV

  公开号：US11052155B2

  公开（公告）日：2021-07-06

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

  本发明涉及 DNA 烷基化剂 CC-1065 的新型类似物及其共轭物。此外，本发明还涉及制备上述制剂和共轭物的中间体。这些共轭物的设计目的是在一个或多个活化步骤之后和/或以共轭物控制的速率和时间跨度释放它们的（多重）有效载荷，以便选择性地递送和/或可控地释放一种或多种所述 DNA 烷化剂。这些制剂、共轭物和中间体可用于治疗以不希望的（细胞）增殖为特征的疾病。例如，本发明的制剂和共轭物可用于治疗肿瘤。
• Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers
  申请人：SYNTARGA BV

  公开号：US20170274090A1

  公开（公告）日：2017-09-28

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• US9629924B2
  申请人：——

  公开号：US9629924B2

  公开（公告）日：2017-04-25
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  申请人：——

  公开号：US9815784B2

  公开（公告）日：2017-11-14
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  申请人：——

  公开号：US9901567B2

  公开（公告）日：2018-02-27