N2,N2,N4,N4,N6,N6-六乙基-1,3,5-三嗪-2,4,6-三胺 | 2827-49-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N2,N2,N4,N4,N6,N6-六乙基-1,3,5-三嗪-2,4,6-三胺
• 中文别名: 2,4,6-三(二乙氨基)-三嗪
• 英文名称: N2,N2,N4,N4,N6,N6-hexaethyl-1,3,5-triazine-2,4,6-triamine
• 英文别名: tris(diethylamino)-s-triazine；hexa-N-ethyl-[1,3,5]triazine-2,4,6-triamine；hexa-N-ethyl-[1,3,5]triazine-2,4,6-triyltriamine；Hexa-N-aethyl-[1,3,5]triazin-2,4,6-triyltriamin；2,4,6-tris(diethylamino)-1,3,5-triazine；2,4,6-Tris(diethylamino)-s-triazin；2-N,2-N,4-N,4-N,6-N,6-N-hexaethyl-1,3,5-triazine-2,4,6-triamine
• CAS: 2827-49-8
• 化学式: C₁₅H₃₀N₆
• 分子量: 294.443
• InChiKey: RLMGHKMNVDBCSB-UHFFFAOYSA-N

物化性质

• 熔点：
  46-47 °C(Solv: methanol (67-56-1))
• 沸点：
  151-154 °C(Press: 2-3 Torr)
• 密度：
  1.043±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 海关编码：
  2933699090

反应信息

• 作为反应物：
  描述：

  盐酸 、 N2,N2,N4,N4,N6,N6-六乙基-1,3,5-三嗪-2,4,6-三胺 生成 二乙胺 、 氰尿酸
  参考文献：
  名称：

  Hofmann, Chemische Berichte, 1885, vol. 18, p. 2778

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(chloroformyl)-N',N'-diethyl-N-methylurea 反应 0.33h， 以60%的产率得到N2,N2,N4,N4,N6,N6-六乙基-1,3,5-三嗪-2,4,6-三胺
  参考文献：
  名称：

  Mironov, V. F.; Kozyukov, V. P.; Orlov, G. I., Journal of general chemistry of the USSR, 1982, vol. 52, p. 1870 - 1874

  摘要：

  DOI：

文献信息

• The umpolung of substituent effect in nucleophilic aromatic substitution. A new approach to the synthesis of N,N-disubstituted melamines (triazine triskelions) under mild reaction conditions
  作者：Beata Kolesinska、Zbigniew J. Kaminski

  DOI：10.1016/j.tet.2009.03.017

  日期：2009.5

  By the umpolung of substituent effect 1,3,5-triazines substituted with three dialkylamino groups were prepared under mild reaction conditions by treatment of cyanuric chloride with tertiary amines. Quaternary N-triazinylammonium salts were identified as reactive intermediates activating the triazine ring and strongly promoting the persubstitution of all chlorine atoms. The final degradation of intermediate

  通过取代基作用的增强，在温和的反应条件下，通过用叔胺处理氰尿酰氯，制备了被三个二烷基氨基取代的1,3,5-三嗪。季Ñ -triazinylammonium盐被鉴定为活性中间体活化三嗪环，并强烈促进所有氯原子的persubstitution。在适当的氯烷烃不可逆转的释放过程中，中间体N-三叠氮基氯化铵的最终降解在室温下或在沸腾的二氯甲烷中自发进行。
• Synthesis and Antiviral Evaluation of Some <i>C</i><sub>3</sub>-Symmetrical Trialkoxy-Substituted 1,3,5-Triazines and Their Molecular Geometry
  作者：Nobuko Mibu、Kazumi Yokomizo、Hatsumi Aki、Norimasa Ota、Hiroyuki Fujii、Ai Yuzuriha、Shiori Saneyoshi、Aoi Tanaka、Airi Koga、Jianrong Zhou、Takeshi Miyata、Kunihiro Sumoto

  DOI：10.1248/cpb.c15-00309

  日期：——

  As one of our projects, we here report some new molecular modifications of 2,4,6-trichloro-1,3,5-triazine (TCTAZ: 1) to symmetrical 2,4,6-trialkoxy- or 2,4,6-triaryloxy-substituted 1,3,5-triazine (TAZ) molecules, as well as the results of anti-herpes simplex virus type 1 (anti-HSV-1) activity evaluation of synthesized 2,4,6-trisubstituted TAZ derivatives. Among the tested 2,4,6-trisubstituted TAZ derivatives, we reconfirmed that a C3-symmetrical TAZ derivative, 4e, shows the highest level of anti-HSV-1 activity with a good selectivity index. In this paper, we also report the results of the preparation of newly targeted TAZ derivatives and the structure–activity relationships (SARs) of these trialkoxy-substituted TAZ derivatives and related compounds. The sugar recognition properties of C3-symmetrical TAZ derivative 4e are also described.

  作为我们的项目之一，我们在此报告了一些新型分子修饰的2,4,6-三氯-1,3,5-三嗪（TCTAZ: 1），将其改为对称的2,4,6-三烷氧基或2,4,6-三芳氧基取代的1,3,5-三嗪（TAZ）分子，以及合成的2,4,6-三取代TAZ衍生物的抗单纯疱疹病毒1型（抗HSV-1）活性评估结果。在测试的2,4,6-三取代TAZ衍生物中，我们再次确认了一个C3对称的TAZ衍生物4e表现出最高的抗HSV-1活性，并具有良好的选择性指数。本文还报告了新靶向TAZ衍生物的制备结果及这些三烷氧基取代的TAZ衍生物和相关化合物的结构-活性关系（SARs）。此外，还描述了C3对称的TAZ衍生物4e的糖识别特性。
• 4,6-Bis- and 2,4,6-tris-(N,N-dialkylamino)-s-triazines: synthesis, NMR spectra and restricted rotations
  作者：Alan R. Katritzky、Daniela C. Oniciu、Ion Ghiviriga、Richard A. Barcock

  DOI：10.1039/p29950000785

  日期：——

  Syntheses of various symmetrically and non-symmetrically trisubstituted triazines are reported. Dynamic NMR (1H and 13C) experiments demonstrate that 2,4,6-tris(dialkylamino)-s-triazines show correlated rotations of the alkyl groups in the dialkylamino moieties. Unsymmetrical 2-chloro-, 2-alkoxy- and 2-aryloxy-4,6-bis(di-n-alkylamino)-s-triazines display two non-equivalent n-alkyl groups, due to the

  报道了各种对称和非对称三取代的三嗪的合成。动态NMR（1 H和13 C）的实验表明，2,4,6-三（二烷基氨基） -小号-triazines示出了在二烷基氨基部分相关联的烷基的旋转。不对称2-氯- ，2-烷氧基和2-芳基-4,6-双（二- ñ -烷基氨基） -小号-triazines显示两个非等价Ñ烷基基团，由于周围的AR-受限旋转N个债券。
• Composition and use of this composition as a stabilizer in lubricating oils, and product obtained
  申请人：The B.F. GOODRICH Company

  公开号：EP0002269A1

  公开（公告）日：1979-06-13

  An antioxidant composition comprising at least one diaromatic amine compound of the formula wherein R, R. and Rc are independently selected from the group consisting of hydrogen and A is alkyl of 1-12 carbon atoms. haloalkyl, aralkyl. mercapto or alkylmercapto; X is alkyl of 1-12 carbon atoms; and n is 0 or 1 with the priviso that where R, R, and Rb are n is 0, or that where only R is n is 1; and at least one substituted melamine compound of the formula wherein Rc through Rh are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl and substituted aryl. The relative weight ratio of formula I to formula II compounds in the composition of this invention can range from about 1:10 to about 10:1. The above compositions are highly affective stabilizers for synthetic lubricants.

  一种抗氧化剂组合物，包含至少一种式中的二芳香族胺化合物 其中 R、R.和 Rc 分别独立地选自氢和以下组成的组 A 是 1-12 个碳原子的烷基、卤代烷基、芳基、巯基或烷基巯基； X 是 1-12 个碳原子的烷基； n 是 0 或 1，但以下情况除外：当 R、R 和 Rb 是 n 为 0，或当只有 R 是 n为1；以及至少一种取代的三聚氰胺化合物，其式如下 其中 Rc 至 Rh 独立选自由氢、烷基、取代烷基、环烷基、芳基和取代芳基组成的组。 本发明组合物中式 I 与式 II 化合物的相对重量比可从约 1:10 到约 10:1。上述组合物是合成润滑油的高效稳定剂。
• Rigid thermoplastic halopolymer compounds and method for reduction of heat release
  申请人：THE B.F. GOODRICH COMPANY

  公开号：EP0568922A1

  公开（公告）日：1993-11-10

  Disclosed are rigid and semi-rigid, impact modified halopolymer compositions and methods for reducing the heat release on exposure to an incident flux by the incorporation of an organo-amine molybdate and antimony oxide. Articles made including extruded sheets, non-sheet profiles and injection molded articles exhibit a total heat release rate of less than 65 kW/m² and a peak heat release rate of 65 kW-min/m² measured by means of the OSU rate of heat release calorimeter according to FAR 25.853. The preferred compound embodiments comprise post-chlorinated polyvinyl chloride, impact modifier, stabilizer, lubricant, melamine molybdate, antimony trioxide, pigment and colorant.

  本发明公开了硬质和半硬质抗冲击改性卤聚合物组合物，以及通过加入有机胺钼酸盐和氧化锑来减少暴露于入射流量时的热释放的方法。包括挤压板材、非板材型材和注塑制品在内的物品的总热释放率低于 65 kW/m²，根据 FAR 25.853，通过 OSU 热释放率量热器测量的峰值热释放率为 65 kW-min/m²。优选的化合物实施例包括后氯化聚氯乙烯、抗冲改性剂、稳定剂、润滑剂、三聚氰胺钼酸盐、三氧化二锑、颜料和着色剂。