2',4'-Dihydroxyacetophenone oxime | 850925-13-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2',4'-Dihydroxyacetophenone oxime
• 英文别名: Resacetophenon-oxim；1-(2,4-dihydroxyphenyl)ethanone oxime；(1E)-1-(2,4-Dihydroxyphenyl)ethanone oxime；4-[(E)-N-hydroxy-C-methylcarbonimidoyl]benzene-1,3-diol
• CAS: 850925-13-2
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: FQPRUMXSHZSJGM-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  73
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2',4'-Dihydroxyacetophenone oxime 在 异丁酰胺 、 三氯氧磷 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以83%的产率得到6-羟基-2-甲基苯并恶唑
  参考文献：
  名称：

  The Beckmann Rearrangement by Means of Phosphoryl Chloride/N,N-Dimethylacetamide; A Novel and Convenient Method for Preparing Benzoxazoles

  摘要：

  DOI：

  10.1055/s-1982-29704
• 作为产物：
  描述：

  2,4-二羟基苯乙酮 、 羟胺 生成 2',4'-Dihydroxyacetophenone oxime
  参考文献：
  名称：

  EL-KASABY, M. A.;SALEM, M. A. I., EGYPT. J. CHEM., 1980, 23, N 2, 123-136

  摘要：

  DOI：

文献信息

• 5-Thioxylopyranose Compounds
  申请人：THOMAS Didier

  公开号：US20090118325A1

  公开（公告）日：2009-05-07

  5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses. The compounds correspond to formula I: in which the pentapyranosyl group represents a free or substituted 5-thio-β-D-xylopyranosyl group; R′, R″ and R′″ each independently represent a hydrogen atom, a C 2 -C 6 acyl group, or two adjacent ones of them form a 1-methylethylidene bridge; X 1 and X 2 each represent carbon or nitrogen; Y 1 and Y 2 each independently represent carbon, nitrogen, sulfur or oxygen, with the proviso that if Y 2 represents oxygen or sulfur, then Y 1 represents carbon or nitrogen; R 1 , R 2 , R 3 , R 4 and R 5 each independently represent hydrogen, a COOR 6 group where R 6 represents hydrogen or a C 1 -C 4 alkyl group optionally substituted by a phenyl ring, a halogen atom or a —COOR 6 group; a C 1 -C 4 alkoxy group; a C 1 -C 6 acyl group; a benzoyl group or a phenyl ring; and the addition salts and/or active metabolites of such compounds.

  含有5-硫氧基木糖化合物，尤其是5-硫氧基吡喃糖化合物，其制备方法，以及它们用于治疗和/或抑制血栓症，尤其是静脉血栓症。这些化合物对应于式I：其中五元吡喃糖基代表自由或取代的5-硫基-β-D-木糖吡喃糖基；R'、R"和R'"各自独立地代表氢原子、C2-C6酰基团，或其中的两个相邻的形成1-甲基乙烯基桥；X1和X2各代表碳或氮；Y1和Y2各自独立地代表碳、氮、硫或氧，但如果Y2代表氧或硫，则Y1代表碳或氮；R1、R2、R3、R4和R5各自独立地代表氢、COOR6基团，其中R6代表氢或C1-C4烷基基团，该基团可选地被苯环、卤素原子或-COOR6基团取代；C1-C4烷氧基团；C1-C6酰基团；苯甲酰基团或苯环；以及这些化合物的盐和/或活性代谢物。
• Novel tricyclic spiropiperidines or spiropyrrolidines
  申请人：Hossain Nafizal

  公开号：US20050245741A1

  公开（公告）日：2005-11-03

  The invention provides compounds of formula (I) wherein m, R 1 , n, R 2 , q, X, Y, Z, R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , t and R 9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供了公式（I）的化合物，其中m、R1、n、R2、q、X、Y、Z、R3、R4、R5、R6、R7、R8、t和R9如规范中所定义，以及它们的制备方法、包含它们的制药组合物及其在治疗中的应用。
• Benzisoxazole Compound
  申请人：Sasaki Atsushi

  公开号：US20090318690A1

  公开（公告）日：2009-12-24

  Disclosed is a compound represented by the general formula (I) or a salt thereof: wherein any one of R1, R2 and R3 represents a group represented by the formula: —(CH 2 )m-NR11R12 (wherein m is 1 or 2; and R11 and R12 independently represent a hydrogen atom or a C1-6 alkyl group or may, together with a nitrogen atom to which R11 and R12 are bound, form a 4- or 5-membered cyclic group); the remaining two or R1, R2 and R3 independently represent a group represented by the formula: —(O)n-R21 (wherein n is 0 or 1; and R21 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the like); and R4 represents a C1-6 alkyl group which may have a substituent or the like.

  本发明涉及一种由通式（I）表示的化合物或其盐：其中R1、R2和R3中的任意一个表示公式表示的基团：—（CH2）m-NR11R12（其中m为1或2；R11和R12独立地表示氢原子或C1-6烷基或可能与R11和R12结合的氮原子一起形成4-或5-成员环状基团）；剩余的两个或R1、R2和R3独立地表示公式表示的基团：—（O）n-R21（其中n为0或1；R21表示氢原子、C1-6烷基、C2-6烯基、C2-6炔基等）；R4表示可能具有取代基的C1-6烷基。
• Novel tricyclic spiroderivatives as modulators of chemokine receptor acitivity
  申请人：Hossain Nafizal

  公开号：US20070099945A1

  公开（公告）日：2007-05-03

  The invention provides compounds of formula (I) wherein m, R 1 , n, R 2 , q, p, X, Y, R 3 , R 4 , t and, R 5 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  该发明提供了式（I）的化合物，其中m，R1，n，R2，q，p，X，Y，R3，R4，t和R5如规范中定义，以及它们的制备方法，含有它们的制药组合物以及它们在治疗中的应用。
• Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
  申请人：Hossain Nafizal

  公开号：US20070021498A1

  公开（公告）日：2007-01-25

  The invention provides compounds of formula (I) wherein m, R 1 , n, R 2 , q, X, Y, Z, R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , t and R 9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  该发明提供了式(I)的化合物，其中m，R1，n，R2，q，X，Y，Z，R3，R4，R5，R6，R7，R8，t和R9如规范中所定义，其制备方法，包含它们的制药组合物以及它们在治疗中的用途。