(2E)-4,4,4-trifluoro-2-[(3-methylphenyl)hydrazinylidene]-1-thiophen-2-ylbutane-1,3-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E)-4,4,4-trifluoro-2-[(3-methylphenyl)hydrazinylidene]-1-thiophen-2-ylbutane-1,3-dione
• 化学式: C₁₅H₁₁F₃N₂O₂S
• 分子量: 340.3
• InChiKey: YNUQHMHMYSUKFL-NDENLUEZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  86.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• METHOD OF SCREENING FOR TRIACYGLYCEROL HYDROLASE INHIBITORS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1206569A2

  公开（公告）日：2002-05-22
• US6861233B1
  申请人：——

  公开号：US6861233B1

  公开（公告）日：2005-03-01
• [EN] METHOD OF SCREENING FOR TRIACYGLYCEROL HYDROLASE INHIBITORS<br/>[FR] PROCEDE PERMETTANT DE CRIBLER DES INHIBITEURS DE TRIACYGLYCEROL-HYDROLASE
  申请人：GLAXO GROUP LTD

  公开号：WO2001016358A2

  公开（公告）日：2001-03-08

  The invention relates to methods of identifying therapeutic agents which inhibit triacyglycerol hydrolase (TGH) activity, defined as TGH inhibitors, which are useful in the treatment of conditions resulting from elevated circulating levels of TG, VLDL/LDL-cholesterol and ApoB-100. Also claimed are therapeutic agents which are TGH inhibitors, identifiable by such methods and their use in combating diseases associated with elevated circulating levels of TG, VLDL/LDL-cholesterol and ApoB-100.