N-[(3-fluorophenyl)methoxy]aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - N-苯基羟胺
• 英文名称: N-[(3-fluorophenyl)methoxy]aniline
• 化学式: C₁₃H₁₂FNO
• 分子量: 217.24
• InChiKey: KYGDOSYDNFIWPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITOR, COMPOSITIONS, METHODS OF MAKING THEM AND THEIR USE
  申请人：Black Diamond Therapeutics, Inc.

  公开号：EP3856726A1

  公开（公告）日：2021-08-04
• [EN] QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITOR, COMPOSITIONS, METHODS OF MAKING THEM AND THEIR USE<br/>[FR] DÉRIVÉS DE QUINAZOLINE UTILISÉS EN TANT QU'INHIBITEUR DE TYROSINE KINASE, COMPOSITIONS, LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION
  申请人：BLACK DIAMOND THERAPEUTICS INC

  公开号：WO2020068867A1

  公开（公告）日：2020-04-02

  The present disclosure relates to new compounds or pharmaceutically acceptable salts or stereoisomers thereof of formula I as inhibitors of receptor tyrosine kinases (RTK), in particular extracellular mutants of ErbB-receptors. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the treatment of cancer in mammals (e.g. humans).