1-Methyl-1,2-dihydropyridin-1-ium-3-carboxamide;chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Methyl-1,2-dihydropyridin-1-ium-3-carboxamide;chloride
• 英文别名: 1-methyl-1,2-dihydropyridin-1-ium-3-carboxamide;chloride
• 化学式: C7H11ClN2O
• 分子量: 174.63
• InChiKey: WOWBGMOQMOMTQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.56
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  47.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] 3-CARBAMOYL-1 -METHYLPYRIDINIUM NITRITE, PROCESS FOR ITS PREPARATION AND ITS USE<br/>[FR] NITRITE DE 3-CARBAMOYL-1-MÉTHYLPYRIDINIUM, PROCÉDÉ POUR SA PRÉPARATION ET SON UTILISATION
  申请人：UNIV JAGIELLOŃSKI

  公开号：WO2014200373A1

  公开（公告）日：2014-12-18

  The invention relates to a novel pyridinium salt comprising an anion in the form of a nitrite and a cation in the form of a 3-carbamoyl-l -methylpyridinium, the process of its preparation and its use for the manufacture of a vascular protective agent for the treatment or prevention of conditions or diseases associated with the dysfunction of vascular endothelium, failure of endothelial synthesis of nitric oxide (NO) and/or failure of endothelial synthesis of prostacyclin (PGI2).

  该发明涉及一种新型吡啶盐，其中包括以亚硝酸盐形式的阴离子和以3-羰基-1-甲基吡啶盐形式的阳离子，以及其制备方法和用于制造血管保护剂的用途，用于治疗或预防与血管内皮功能障碍、内皮合成一氧化氮（NO）失调和/或内皮合成前列环素（PGI2）失调相关的疾病或症状。
• HERBICIDAL COMPOSITIONS AND METHODS OF USE
  申请人：Pernak Juliusz

  公开号：US20130109572A1

  公开（公告）日：2013-05-02

  Disclosed are compositions and methods of preparing compositions of active herbicidal ingredients. Also disclosed are methods of using the compositions described herein to improve herbicide delivery and efficacy, enhance herbicidal penetration, reduce herbicide volatility and drift, diminish environmental damage from herbicides, decrease water solubility and volatility of herbicides, and introduce additional biological function to herbicides.

  本发明涉及活性除草成分的组合物和制备方法。同时，本发明还涉及使用所述组合物的方法，以改善除草剂的输送和功效，增强除草剂的渗透性，减少除草剂的挥发和漂移，减少除草剂对环境的损害，降低除草剂的水溶性和挥发性，并为除草剂引入额外的生物功能。
• The use of quaternary pyridinium salts as vasoprotective agents
  申请人：Pharmena SA

  公开号：EP2279738A1

  公开（公告）日：2011-02-02

  The invention relates to the use of quaternary pyridinium salts of formula I, wherein wherein R is NH2, CH3, or N(H)CH2OH, and X- is a pharmaceutically acceptable counterion, for the preparation of vasoprotective agent or a dietary supplement for the treatment or prevention of conditions or diseases associated with dysfunction of vascular endothelium, oxidative stress, and/or insufficient production of endothelial prostacyclin PGI2, in particular but not exclusively if the above coincides with hypercholesterolemia, hypertriglyceridemia or low HDL level.

  本发明涉及式 I 的季铵盐，其中 R 为 NH2、CH3 或 N(H)CH2OH，X- 为药学上可接受的反离子，用于制备血管保护剂或膳食补充剂，以治疗或预防与血管内皮功能障碍相关的病症或疾病、氧化应激和/或血管内皮前列环素 PGI2 生成不足，特别是但不限于上述与高胆固醇血症、高甘油三酯血症或高密度脂蛋白水平低有关的情况或疾病。
• Method of treating endothelial dysfunction
  申请人：Celagenex Research (India) Pvt. Ltd.

  公开号：US10864207B2

  公开（公告）日：2020-12-15

  The present invention herein discloses potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function. Particularly, the invention relates to synergistic nutritional composition comprising exogenous blend of N1-methyl nicotinamide chloride and standardized red spinach extract enriched with nitrate content along with pharmaceutically acceptable excipients, wherein N1-methyl nicotinamide salt and standardized red spinach extract enriched with nitrate content are present in the ratio of 1:0.5 to 1:8; and N1-methyl nicotinamide chloride and nitrate of standardized red spinach extract, are present in the ratio of 1:0.1 to 1:1. The present synergistic composition is useful for treating endothelial dysfunction such as hypertension, atherosclerosis, thrombosis, myocardial infarction, heart injury.

  本发明公开了用于改善血管内皮功能的血管活性介质增强剂的强效协同组合物。特别是，本发明涉及由氯化 N1-甲基烟酰胺和富含硝酸盐的标准化红菠菜提取物以及药学上可接受的赋形剂组成的外源混合协同营养组合物，其中氯化 N1-甲基烟酰胺盐和富含硝酸盐的标准化红菠菜提取物的比例为 1:0.5 至 1:8；氯化 N1-甲基烟酰胺和标准化红菠菜提取物的硝酸盐的比例为 1:0.1 至 1:1。本增效组合物可用于治疗高血压、动脉粥样硬化、血栓形成、心肌梗塞、心脏损伤等内皮功能障碍。
• Peptide-containing formulations
  申请人：COHBAR, INC.

  公开号：US11517608B2

  公开（公告）日：2022-12-06

  A formulation comprising glutamic acid, or a salt thereof, and an effective amount of a peptide is provided. The invention also provides a method of preparing the formulation, methods of treating a condition using the formulation, and a kit containing components of the formulation. The invention further provides a sustained release formulation for drug substances comprising glutamic acid, or a salt thereof, and an amount of a peptide.

  本发明提供了一种包含谷氨酸或其盐以及有效量肽的制剂。本发明还提供了制备该制剂的方法、使用该制剂治疗疾病的方法以及含有该制剂成分的试剂盒。本发明进一步提供了一种药物物质的缓释制剂，该制剂包含谷氨酸或其盐以及一定量的肽。