4-[2-Amino-1-(3,4-dihydroxyphenyl)ethoxy]-2,3-dihydroxy-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-Amino-1-(3,4-dihydroxyphenyl)ethoxy]-2,3-dihydroxy-4-oxobutanoic acid
• 英文别名: 4-[2-amino-1-(3,4-dihydroxyphenyl)ethoxy]-2,3-dihydroxy-4-oxobutanoic acid
• 化学式: C₁₂H₁₅NO₈
• 分子量: 301.25
• InChiKey: OGLDSCXVUGFPFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  171
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• PARENTERAL DOSAGE FORM OF NOREPINEPHRINE
  申请人：Sun Pharmaceutical Industries Ltd

  公开号：EP2990031A1

  公开（公告）日：2016-03-02

  The present invention relates to a ready-to-administer parenteral dosage form of norepinephrine which comprises an aqueous solution of norepinephrine, having an anti-oxidant which is not a sulfite anti-oxidant, wherein the dosage form is stable at room temperature for prolonged period of time.

  本发明涉及一种去甲肾上腺素的即用型肠外剂型，它由去甲肾上腺素水溶液和一种非亚硫酸盐抗氧化剂组成，其中该剂型在室温下可长期稳定使用。
• Process for the preparation of l-Norepinephrine bitartrate monohydrate having high enantiomeric purity
  申请人：HARMAN FINOCHEM LIMITED

  公开号：US10865180B2

  公开（公告）日：2020-12-15

  The present invention, discloses optically pure compounds of l-Norepinephrine and its acid addition salts and hydrates and process for the preparation thereof. Specifically, the present invention discloses optically pure compounds of l-Norepinephrine bitartrate, its process of preparation and pharmaceutical compositions comprising the same.

  本发明公开了光学纯的l-去甲肾上腺素化合物及其酸加成盐和水合物及其制备工艺。具体而言，本发明公开了酒石酸去甲肾上腺素的光学纯化合物、其制备工艺以及包含这些化合物的药物组合物。
• Parenteral dosage form of norepinephrine
  申请人：SUN PHARMACEUTICAL INDUSTRIES LIMITED

  公开号：US11166923B2

  公开（公告）日：2021-11-09

  The present invention relates to a ready-to-administer parenteral dosage form of norepinephrine which comprises an aqueous solution of norepinephrine, having an anti-oxidant which is not a sulfite anti-oxidant, wherein the dosage form is stable at room temperature for prolonged period of time.

  本发明涉及一种去甲肾上腺素的即用型肠外剂型，它由去甲肾上腺素水溶液和一种非亚硫酸盐抗氧化剂组成，其中该剂型在室温下可长期稳定使用。
• Antioxidant free, norepinephrine bitartrate injection in amber glass vials
  申请人：Medefil, Inc.

  公开号：US11331266B1

  公开（公告）日：2022-05-17

  The application provides pharmaceutical compositions comprising stable concentrated solutions of antioxidant free norepinephrine bitartrate for injection dispensed in glass containers and methods of providing such solutions to a subject.

  本申请提供的药物组合物包含在玻璃容器中分配的注射用抗氧化剂游离酒石酸去甲肾上腺素的稳定浓缩溶液，以及向受试者提供这种溶液的方法。
• PROCESS FOR THE PREPARATION OF l-NOREPINEPHRINE BITARTRATE MONOHYDRATE HAVING HIGH ENANTIOMERIC PURITY
  申请人：HARMAN FINOCHEM LIMITED

  公开号：US20200048185A1

  公开（公告）日：2020-02-13

  The present invention, discloses optically pure compounds of l-Norepinephrine and its acid addition salts and hydrates and process for the preparation thereof. Specifically, the present invention discloses optically pure compounds of l-Norepinephrine bitartrate, its process of preparation and pharmaceutical compositions comprising the same.