(E)-N'-(p-chlorophenyl)isopicolinohydrazonyl cyanide | 1362165-67-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N'-(p-chlorophenyl)isopicolinohydrazonyl cyanide
• 英文别名: (4E)-N-(4-chloroanilino)pyridine-4-carboximidoyl cyanide
• CAS: 1362165-67-0
• 化学式: C₁₃H₉ClN₄
• 分子量: 256.694
• InChiKey: WWGBNCBTGWCWOD-AQTBWJFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对氯苯胺 、 2-(吡啶-4-基)乙腈 在 盐酸 、 sodium nitrite 、 sodium acetate 作用下， 以 水 、 乙醇 为溶剂， 以70%的产率得到(E)-N'-(p-chlorophenyl)isopicolinohydrazonyl cyanide
  参考文献：
  名称：

  Synthesis, spectral characterization and in vitro antimicrobial activity of some new azopyridine derivatives

  摘要：

  A series of arylpicolino and/or isonicotinohydrazonyl cyanide 2a-d and 4a-f were prepared by coupling the approprite aryl diazonium salt with 2-cyanomethyl and/or 4-cyanomethyl-pyridine, respectively. These compounds were characterized by analytical and spectral analyses and screened for their antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and antifungal activity. Among the synthesized compounds, N'-(4-phenyldiazenyl)phenylisonicotinohydrazonyl cyanide 4f showed a significant activity toward both Gram-positive. Gram-negative bacteria and exhibit the most potent in vitro antifungal with MIC's (625 mu g/mL) against Aspergillus nieger. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.12.054

文献信息

• Synthesis, spectral characterization and in vitro antimicrobial activity of some new azopyridine derivatives
  作者：Hanaa Abuo-Melha、A.A. Fadda

  DOI：10.1016/j.saa.2011.12.054

  日期：2012.4

  A series of arylpicolino and/or isonicotinohydrazonyl cyanide 2a-d and 4a-f were prepared by coupling the approprite aryl diazonium salt with 2-cyanomethyl and/or 4-cyanomethyl-pyridine, respectively. These compounds were characterized by analytical and spectral analyses and screened for their antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and antifungal activity. Among the synthesized compounds, N'-(4-phenyldiazenyl)phenylisonicotinohydrazonyl cyanide 4f showed a significant activity toward both Gram-positive. Gram-negative bacteria and exhibit the most potent in vitro antifungal with MIC's (625 mu g/mL) against Aspergillus nieger. (C) 2011 Elsevier B.V. All rights reserved.