2-(2,6-Dichlorophenyl)imino-5-[2-(4-ethylpiperazin-1-yl)-2-oxoethylidene]-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,6-Dichlorophenyl)imino-5-[2-(4-ethylpiperazin-1-yl)-2-oxoethylidene]-1,3-thiazolidin-4-one
• 英文别名: 2-(2,6-dichlorophenyl)imino-5-[2-(4-ethylpiperazin-1-yl)-2-oxoethylidene]-1,3-thiazolidin-4-one
• 化学式: C₁₇H₁₈Cl₂N₄O₂S
• 分子量: 413.3
• InChiKey: KSQGMCZSCVFVCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  90.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：——

  公开号：US20030162779A1

  公开（公告）日：2003-08-28

  The invention relates to BCAT inhibitors and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

  本发明涉及BCAT抑制剂及其用于治疗或预防与中风、缺血、中枢神经系统创伤、低血糖和手术相关的神经元丢失，以及治疗包括阿尔茨海默病、肌萎缩性侧索硬化症、亨廷顿病和唐氏综合症在内的神经退行性疾病，治疗或预防兴奋性氨基酸过度刺激的不良后果，治疗焦虑、精神病、惊厥、氨基糖苷类抗生素引起的听力损失、偏头痛、慢性疼痛、神经病性疼痛、帕金森病、糖尿病视网膜病变、青光眼、CMV视网膜炎、尿失禁、阿片类药物耐受或戒断，并诱导麻醉，以及增强认知的用途。
• Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1314426A9

  公开（公告）日：2003-09-17

  The invention relates to BCAT inhibitors and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

  本发明涉及 BCAT 抑制剂及其用于治疗或预防与中风、缺血、中枢神经系统创伤、低血糖和手术相关的神经元损失，以及治疗神经退行性疾病，包括阿尔茨海默病、肌萎缩性脊髓侧索硬化症、亨廷顿氏病和唐氏综合征、治疗或预防兴奋性氨基酸过度刺激的不良后果，治疗焦虑、精神病、抽搐、氨基糖苷类抗生素引起的听力损失、偏头痛、慢性疼痛、神经性疼痛、帕金森病、糖尿病视网膜病变、青光眼、CMV 视网膜炎、尿失禁、阿片类药物耐受或戒断、诱导麻醉以及增强认知能力。
• US6632831B2
  申请人：——

  公开号：US6632831B2

  公开（公告）日：2003-10-14
• [EN] BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] INHIBITEURS D'AMINOTRANSFERASE SPECIFIQUE D'ACIDES AMINES A CHAINE RAMIFIEE, ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES NEURODEGENERATIVES
  申请人：WARNER LAMBERT CO

  公开号：WO2003045384A1

  公开（公告）日：2003-06-05

  The invention relates to BCAT inhibitors and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative dieseases including Alzheimer's disease, amyotrophic lateral ssclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's diesease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.