(R)-2-Amino-2-methyl-3-phenyl-propionic acid butyl ester | 141784-96-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-Amino-2-methyl-3-phenyl-propionic acid butyl ester
• 英文别名: butyl (2R)-2-amino-2-methyl-3-phenylpropanoate
• CAS: 141784-96-5
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: UFFLHYAPEHSQFN-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-Amino-2-methyl-3-phenyl-propionic acid butyl ester 以 various solvent(s) 为溶剂， 生成 2-甲基-L-苯丙氨酸一水物 、 (R)-2-Amino-2-methyl-3-phenyl-propionic acid butyl ester
  参考文献：
  名称：

  Biocatalytic resolution of tertiary .alpha.-substituted carboxylic acid esters: efficient preparation of a quaternary asymmetric carbon center

  摘要：

  A method for resolving a variety of tertiary alpha-substituted carboxylic acid

  DOI：

  10.1021/jo00039a004

文献信息

• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING alpha-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：Maruoka Keiji

  公开号：US20070135654A1

  公开（公告）日：2007-06-14

  The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.
• Optically active quaternary ammonium salt having axial asymmetry and process for producing alpha-amino acid and derivative thereof with the same
  申请人：Maruoka Keiji

  公开号：US20070161624A1

  公开（公告）日：2007-07-12

  The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.
• US8716524B2
  申请人：——

  公开号：US8716524B2

  公开（公告）日：2014-05-06
• Biocatalytic resolution of tertiary .alpha.-substituted carboxylic acid esters: efficient preparation of a quaternary asymmetric carbon center
  作者：Christopher Yee、Todd A. Blythe、Thomas J. McNabb、Alan E. Walts

  DOI：10.1021/jo00039a004

  日期：1992.6

  A method for resolving a variety of tertiary alpha-substituted carboxylic acid