4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime | 115499-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime
• 英文别名: ethyl 4-[bis(4-methoxyphenyl)methylideneamino]oxy-3-methoxyiminobutanoate
• CAS: 115499-87-1
• 化学式: C₂₂H₂₆N₂O₆
• 分子量: 414.458
• InChiKey: GRLDFOLDIXRZRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  87.9
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime 以 甲醇 为溶剂， 生成 4,4'-dimethoxybenzophenone O-(3-carboxy-2-methoxyiminopropyl)oxime
  参考文献：
  名称：

  Diphenyl-methane compounds useful in the treatment of diseases caused by

  摘要：

  一种新的二苯甲烷衍生物，用于抑制血液凝聚，其定义由以下化学式确定，包括二苯乙烯衍生物和苯甲酮肟醚衍生物。其中R1和R2分别为氢、羟基或较低的烷氧基，U为.dbd.CXY或.dbd.N--O--W，X为氢、氰基或--COR6，R6为羟基或氨基，Y为--R10--COOR3，R3为氢或较低的烷氧基，R10为1至3个碳原子的直链或支链烷基，--CO--NR4R5，R4和R5分别为氢、较低的烷基或较低的芳基烷基，--CH2--NHSO2--C6H5或--C(R8).dbd.NR7，R7为较低的烷氧基或芳基，R8为--VR9，V为氧、硫或氮，R9为烷基或芳基，W为--CH2--CO--CH2--COOR13，R13为氢或较低的烷基，--CH2--C(C.dbd.NOR14)--CH2--COOR15，R15为氢或较低的烷基，R14为较低的烷基，--CH(CN)--(CH2)q--COOR16，R16为氢或较低的烷基，q为1至3的整数，或--(CH2)p--Z，Z为--SH、--SCN或由五元或六元环衍生的一价基团，该环可能被一个或多个硫原子取代，p为1或2。

  公开号：

  US04886834A1
• 作为产物：
  描述：

  4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-oxopropyl)oxime 、 甲氧基胺盐酸盐 以 吡啶 为溶剂， 生成 4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime
  参考文献：
  名称：

  Diphenyl-methane compounds useful in the treatment of diseases caused by

  摘要：

  一种新的二苯甲烷衍生物，用于抑制血液凝聚，其定义由以下化学式确定，包括二苯乙烯衍生物和苯甲酮肟醚衍生物。其中R1和R2分别为氢、羟基或较低的烷氧基，U为.dbd.CXY或.dbd.N--O--W，X为氢、氰基或--COR6，R6为羟基或氨基，Y为--R10--COOR3，R3为氢或较低的烷氧基，R10为1至3个碳原子的直链或支链烷基，--CO--NR4R5，R4和R5分别为氢、较低的烷基或较低的芳基烷基，--CH2--NHSO2--C6H5或--C(R8).dbd.NR7，R7为较低的烷氧基或芳基，R8为--VR9，V为氧、硫或氮，R9为烷基或芳基，W为--CH2--CO--CH2--COOR13，R13为氢或较低的烷基，--CH2--C(C.dbd.NOR14)--CH2--COOR15，R15为氢或较低的烷基，R14为较低的烷基，--CH(CN)--(CH2)q--COOR16，R16为氢或较低的烷基，q为1至3的整数，或--(CH2)p--Z，Z为--SH、--SCN或由五元或六元环衍生的一价基团，该环可能被一个或多个硫原子取代，p为1或2。

  公开号：

  US04886834A1

文献信息

• Diphenylethylene derivatives pharmaceutical compositions containing same
  申请人：Eisai Co., Ltd.

  公开号：US05182301A1

  公开（公告）日：1993-01-26

  A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W, X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl, W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCH or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

  一种新的二苯甲烷衍生物，有助于抑制血液凝聚，并由式定义，其中包括二苯乙烯衍生物和苯并苦肟醚衍生物。 ##STR1## 其中R1和R2分别为氢，羟基或较低的烷氧基，U为.dbd.CXY或.dbd.N--O--W，X为氢，氰基或--COR6，R6为羟基或氨基，Y为--R10--COOR3，R3为氢或较低的烷氧基，R10为具有1到3个碳原子的直链或支链烷基，--CO--NR4R5，R4和R5分别为氢，较低的烷基或较低的芳基烷基，--CH2--NHSO2--C6H5或--C(R8).dbd.NR7，R7为较低的烷氧基或芳基，R8为--VR9，V为氧，硫或氮，R9为烷基或芳基，W为--CH2--CO--CH2--COOR13，R13为氢或较低的烷基，--CH2--C(.dbd.NOR14)--CH2--COOR15，R15为氢或较低的烷基，R14为较低的烷基，--CH(CN)--(CH2)q--COOR16，R16为氢或较低的烷基，q为1到3的整数，或--(CH2)p--Z，Z为--SH，--SCH或由一个五元或六元环衍生的一价基团，该环可能被一个含有一个或多个硫原子的环取代，p为1或2。
• Benzophenone oxime ether compounds, pharmaceutical compositions and
  申请人：Eisai Co., Ltd.

  公开号：US04954523A1

  公开（公告）日：1990-09-04

  A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W, X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower aralalkyl, --CH2--NHSO3--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl, W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

  一种新的二苯甲烷衍生物，用于抑制血液凝聚，其公式包括二苯乙烯衍生物和苯甲酮肟醚衍生物。 ##STR1## 其中R1和R2分别为氢，羟基或低级烷氧基，U为.dbd.CXY或.dbd.N - O - W，X为氢，氰或 -COR6，R6为羟基或氨基，Y为 -R10- COOR3，R3为氢或低级烷氧基，R10为具有1至3个碳原子的直链或支链烷基，-CO-NR4R5，R4和R5分别为氢，低级烷基或低级芳基烷基，-CH2-NHSO3-C6H5或-C（R8）.dbd.NR7，R7为低级烷氧基或芳基，R8为-VR9，V为氧，硫或氮，R9为烷基或芳基，W为-CH2-CO-CH2-COOR13，R13为氢或低级烷基，-CH2-C(.dbd.NOR14)-CH2-COOR15，R15为氢或低级烷基，R14为低级烷基，-CH（CN）-（CH2）q-COOR16，R16为氢或低级烷基，q为1至3的整数，或-（CH2）p-Z，其中Z为-SH，-SCN或从五元或六元环衍生的一价基团，该环可能被一个或多个硫原子取代，p为1或2。
• Diphenylethylene derivative and pharmaceutical use
  申请人：Eisai Co., Ltd.

  公开号：US04978767A1

  公开（公告）日：1990-12-18

  A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W, X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl, W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

  一种新的二苯甲烷衍生物，用于抑制血液凝聚，其由以下的公式定义，包括一个二苯乙烯衍生物和一个苯并苦肟醚衍生物。 ##STR1## 其中，R1和R2各自为氢、羟基或较低的烷氧基，U为.dbd.CXY或.dbd.N--O--W，X为氢、氰基或--COR6，R6为羟基或氨基，Y为--R10--COOR3，R3为氢或较低的烷氧基，R10为具有1至3个碳原子的直链或支链烷基，--CO--NR4R5，R4和R5各自为氢、较低的烷基或较低的芳基烷基，--CH2--NHSO2--C6H5或--C(R8).dbd.NR7，R7为较低的烷氧基或芳基，R8为--VR9，V为氧、硫或氮，R9为烷基或芳基，W为--CH2--CO--CH2--COOR13，R13为氢或较低的烷基，--CH2--C(.dbd.NOR14)--CH2--COOR15，R15为氢或较低的烷基，R14为较低的烷基，--CH(CN)--(CH2)q--COOR16，R16为氢或较低的烷基，q为1至3的整数，或--(CH2)p--Z，Z为--SH、--SCN或由一个有五个或六个成员的环衍生的一价基团，该环可以被一个或多个硫原子取代，p为1或2。
• Diphenylethylene derivatives, pharmaceutical compositions containing
  申请人：Eisai Co., Ltd.

  公开号：US05206403A1

  公开（公告）日：1993-04-27

  A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime either derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W, X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COR6, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl, W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

  一种新的二苯甲烷衍生物，用于抑制血液凝聚，其化学式包括二苯乙烯衍生物和苯甲酮肟衍生物。## STR1 ## 其中R1和R2分别为氢，羟基或较低的烷氧基，U为.dbd.CXY或.dbd.N--O--W，X为氢，氰基或--COR6，R6为羟基或氨基，Y为--R10--COR6，R3为氢或较低的烷氧基，R10为具有1至3个碳原子的直链或支链烷基，--CO--NR4R5，R4和R5分别为氢，较低的烷基或较低的芳基烷基，--CH2--NHSO2--C6H5或--C（R8）.dbd.NR7，其中R7为较低的烷氧基或芳基，R8为--VR9，V为氧，硫或氮，R9为烷基或芳基，W为--CH2--CO--CH2--COOR13，R13为氢或较低的烷基，--CH2--C（.dbd.NOR14）--CH2--COOR15，其中R15为氢或较低的烷基，R14为较低的烷基，--CH（CN）--（CH2）q--COOR16，其中R16为氢或较低的烷基，q为1至3的整数，或--（CH2）p--Z，其中Z为--SH，--SCN或由五或六元环衍生的一价基团，该环可以被一个或多个硫原子取代，p为1或2。
• Diphenyl-methane compounds useful in the treatment of diseases caused by
  申请人：Eisai Co., Ltd.

  公开号：US04886834A1

  公开（公告）日：1989-12-12

  A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W, X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl, W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(C.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

  一种新的二苯甲烷衍生物，用于抑制血液凝聚，其定义由以下化学式确定，包括二苯乙烯衍生物和苯甲酮肟醚衍生物。其中R1和R2分别为氢、羟基或较低的烷氧基，U为.dbd.CXY或.dbd.N--O--W，X为氢、氰基或--COR6，R6为羟基或氨基，Y为--R10--COOR3，R3为氢或较低的烷氧基，R10为1至3个碳原子的直链或支链烷基，--CO--NR4R5，R4和R5分别为氢、较低的烷基或较低的芳基烷基，--CH2--NHSO2--C6H5或--C(R8).dbd.NR7，R7为较低的烷氧基或芳基，R8为--VR9，V为氧、硫或氮，R9为烷基或芳基，W为--CH2--CO--CH2--COOR13，R13为氢或较低的烷基，--CH2--C(C.dbd.NOR14)--CH2--COOR15，R15为氢或较低的烷基，R14为较低的烷基，--CH(CN)--(CH2)q--COOR16，R16为氢或较低的烷基，q为1至3的整数，或--(CH2)p--Z，Z为--SH、--SCN或由五元或六元环衍生的一价基团，该环可能被一个或多个硫原子取代，p为1或2。