bicyclo[3.2.1]octan-3-amine hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bicyclo[3.2.1]octan-3-amine hydrochloride
• 英文别名: Bicyclo[3.2.1]octan-3-amine hydrochloride；bicyclo[3.2.1]octan-3-amine;hydrochloride
• 化学式: C₈H₁₅N*ClH
• 分子量: 161.675
• InChiKey: CEMXONYLWNOMMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.95
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 、 bicyclo[3.2.1]octan-3-amine hydrochloride 在 N-甲基咪唑 、 N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以25.89%的产率得到N-(3-bicyclo[3.2.1]octanyl)-4-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide
  参考文献：
  名称：

  WO2021062316A5

  摘要：

  公开号：

  WO2021062316A5

文献信息

• COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
  申请人：IFM Due, Inc.

  公开号：US20200172534A1

  公开（公告）日：2020-06-04

  This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.