2-chloro-3-ethylsulfonyl-N-(5-methyl-1,3,4-oxadiazol-2-yl)-4-(trifluoromethyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-3-ethylsulfonyl-N-(5-methyl-1,3,4-oxadiazol-2-yl)-4-(trifluoromethyl)benzamide
• 化学式: C₁₃H₁₁ClF₃N₃O₄S
• 分子量: 397.76
• InChiKey: XBPJLQCWCNLXTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• HPPD variants and methods of use
  申请人：BASF Agricultural Solutions Seed, US LLC

  公开号：US10597674B2

  公开（公告）日：2020-03-24

  In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.

  本发明描述了 HPPD 多肽和含有这些多肽的植物，它们对属于不同化学类别的一种或多种 HPPD 抑制剂除草剂具有完全耐受性。本发明设计了一组突变型 HPPD 多肽，它们对 HPPD 抑制剂除草剂没有亲和力或亲和力明显降低，同时，突变型 HPPD 多肽的 HPPD 抑制剂的解离率增加，以至于 HPPD 抑制剂不再是慢速结合或慢速紧密结合抑制剂，而是成为完全可逆的抑制剂。特别是提供了编码突变型 HPPD 多肽的分离多核苷酸，这些多肽对属于各种化学类别的 HPPD 抑制剂除草剂具有耐受性。此外，还包括与多核苷酸相对应的氨基酸序列。
• HPPD VARIANTS AND METHODS OF USE
  申请人：Bayer CropScience AG

  公开号：EP3347475A1

  公开（公告）日：2018-07-18
• [EN] HPPD VARIANTS AND METHODS OF USE<br/>[FR] VARIANTS DE LA HPPD ET PROCÉDÉ D'UTILISATION
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2017042259A1

  公开（公告）日：2017-03-16

  In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
• [EN] HPPD VARIANTS AND METHODS OF USE<br/>[FR] VARIANTS DE HPPD ET PROCÉDÉS D'UTILISATION
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2018162329A1

  公开（公告）日：2018-09-13

  In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.