3-(6,7-Dimethoxy-4-methyl-2-oxo-2H-quinazolin-1-yl)-propionic acid | 143697-62-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(6,7-Dimethoxy-4-methyl-2-oxo-2H-quinazolin-1-yl)-propionic acid
• 英文别名: 3-(6,7-Dimethoxy-4-methyl-2-oxoquinazolin-1-yl)propanoic acid
• CAS: 143697-62-5
• 化学式: C₁₄H₁₆N₂O₅
• 分子量: 292.291
• InChiKey: IXKKLRCPPQXBNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  88.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  potassium cyanate 、 N-(2-acetyl-4,5-dimethoxyphenyl)-β-alanine 以 溶剂黄146 为溶剂， 反应 1.5h， 以18%的产率得到3-(6,7-Dimethoxy-4-methyl-2-oxo-2H-quinazolin-1-yl)-propionic acid
  参考文献：
  名称：

  Synthesis and renal vasodilator activity of substituted [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic acids

  摘要：

  The synthesis and cardiovascular evaluation of a novel series of [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic esters and acids (II) as renal vasodilators is presented. The compound 3-[6.7-dihydroxy-4-methyl-(1H)-quinazoline-2-one-1-yl]propanoic acid (7) was found to be a potent and selective renal vasodilator.

  DOI：

  10.1016/0223-5234(92)90012-p

文献信息

• Synthesis and renal vasodilator activity of substituted [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic acids
  作者：RK Russell、MA Appollina、V Bandurco、DW Combs、RM Kanojia、R Mallory、E Malloy、JJ McNally、DM Mulvey、Y Gray-Nunez、MS Rampulla、RA Rampulla、SA Sisk、L Williams、SD Levine、SC Bell、EC Giardino、R Falotico、AJ Tobia

  DOI：10.1016/0223-5234(92)90012-p

  日期：1992.4

  The synthesis and cardiovascular evaluation of a novel series of [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic esters and acids (II) as renal vasodilators is presented. The compound 3-[6.7-dihydroxy-4-methyl-(1H)-quinazoline-2-one-1-yl]propanoic acid (7) was found to be a potent and selective renal vasodilator.