4-Diphenylacetoxy-1,1-dimethyl-piperidinium | 81405-11-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Diphenylacetoxy-1,1-dimethyl-piperidinium
• 英文别名: 4-DAMP；4-Diphenylacetoxy-1,1-dimethylpiperidinium；(1,1-dimethylpiperidin-1-ium-4-yl) 2,2-diphenylacetate
• CAS: 81405-11-0
• 化学式: C₂₁H₂₆NO₂
• 分子量: 324.443
• InChiKey: HYJRTXSYDAFGJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Compounds, Compositions and Methods for Treatment of Myopia
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US20200247760A1

  公开（公告）日：2020-08-06

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

  本文提供了8-甲基-8-氮杂双环[3.2.1]辛烷-3-基和吡啶-4-甲基酯和酰胺化合物及其组合物。本文还提供了一种预防或延迟需要该治疗的患者近视发生的方法，包括向该患者施用本文提供的化合物或组合物。本文还提供了一种减缓或预防需要该治疗的患者近视进展的方法，包括向该患者施用本文提供的化合物或组合物。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Therapeutic compositions for diabetic symmetrical polyneuropathy
  申请人：Fernyhough Paul

  公开号：US10307428B2

  公开（公告）日：2019-06-04

  Compositions for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof, the compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.

  用于治疗糖尿病对称性多发性神经病变的组合物，该组合物包括：有效量的毒蕈碱乙酰胆碱受体拮抗剂，例如哌仑西平、替氮平、阿托品或其衍生物或其盐或其类似物或其衍生物，以及药理学上可接受的载体。该组合物可以注射，也可以局部使用，还可以口服。合适的局部组合物可包括乳液、膏霜、凝胶或粘稠液体。毒蕈碱乙酰胆碱受体拮抗剂可以是毒蕈碱乙酰胆碱受体拮抗剂盐或毒蕈碱乙酰胆碱受体拮抗剂衍生物或毒蕈碱乙酰胆碱受体拮抗剂类似物。
• Compounds, compositions and methods for treatment of myopia
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US11117869B2

  公开（公告）日：2021-09-14

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

  本文提供了8-甲基-8-氮杂双环[3.2.1]辛烷-3-基和吡啶-4-基甲烷酯和酰胺化合物及组合物。本文还提供了预防或延迟有需要的受试者近视发生的方法，包括向受试者施用本文提供的化合物或组合物。本文还提供了减少或预防有需要的受试者近视发展的方法，包括对受试者施用本文提供的化合物或组合物。
• Methods of treating or preventing preterm labor
  申请人：Visco Anthony G.

  公开号：US11179393B2

  公开（公告）日：2021-11-23

  Described herein are methods for treating preterm labor, stopping labor prior to Cesarean delivery, preventing preterm labor, or controlling the timing of parturition by administering a chemical compound, such as a muscarinic receptor antagonist preferably a M, receptor antagonist, or a β-3 adrenergic agonist. Also described are methods for treating preterm labor, stopping labor preparatory to Cesarean delivers', preventing preterm labor, or controlling the timing of parturition by administering an effective amount of transdermal stimulation, posterior tibial nerve stimulation or another form of non-invasive or invasive neuromodulation, unstimulated or stimulated acupuncture, magnetic field therapy, or vibratory stimulation. These methods may be practiced individually, in combination with each other, or in combination with known tocolytic methods or medications.

  本文描述了通过施用化合物，如毒蕈碱受体拮抗剂，优选M受体拮抗剂或β-3肾上腺素能激动剂，治疗早产、停止剖宫产前的分娩、预防早产或控制分娩时间的方法。还描述了通过给予有效量的经皮刺激、胫后神经刺激或另一种形式的非侵入性或侵入性神经调节、非刺激或刺激性针灸、磁场疗法或振动刺激来治疗早产、停止剖宫产前的准备性分娩、预防早产或控制分娩时间的方法。这些方法可以单独使用，也可以相互结合使用，或与已知的溶血方法或药物结合使用。