n-(1-Hydroxy-1-phenylpropan-2-yl)tetradecanamide | 919770-84-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: n-(1-Hydroxy-1-phenylpropan-2-yl)tetradecanamide
• CAS: 919770-84-6
• 化学式: C₂₃H₃₉NO₂
• 分子量: 361.6
• InChiKey: YLAZEWZHIRBZDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Cosmetic Composition Containing Calcium Citrate And N-Acylated Aminoalcohol Derivative To Prevent Dry Skin And Signs Of Cutaneous Ageing
  申请人：Moussou Philippe

  公开号：US20120016032A1

  公开（公告）日：2012-01-19

  Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.

  含有柠檬酸钙和至少一种按照公式（I）的N-酰化氨基醇的化妆品组合物。提供了一种治疗老化皮肤的方法，包括将公式（I）的化合物以有效量局部涂抹于老化皮肤上，以提供抗衰老效果。公式（I）的化合物用于防止皮肤老化和/或帮助维持或改善水分保持和/或对抗皮肤老化迹象。公式（I）的N-酰化氨基醇作为角鲨烷酸酶抑制剂。至少一种公式（I）化合物和柠檬酸钙的组合刺激角质细胞分化。
• Cosmetic Composition
  申请人：Cognis IP Management GmbH

  公开号：US20140086863A1

  公开（公告）日：2014-03-27

  Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.

  含有柠檬酸钙和至少一种按照公式(I)的N-酰化氨基醇的化妆品组合物。提供了一种治疗老化皮肤的方法，包括局部涂抹一种含有公式(I)化合物的组合物于老化皮肤上，该化合物的用量足以提供抗衰老效果。公式(I)化合物用于预防皮肤和/或帮助维持或改善保湿性能和/或对抗皮肤衰老迹象。公式(I)的N-酰化氨基醇作为角质酸酶抑制剂。公式(I)化合物和柠檬酸钙的组合刺激角质细胞分化。
• INHIBITION OF CANCER CELL MOTILITY
  申请人：Northwestern University

  公开号：US20160128973A1

  公开（公告）日：2016-05-12

  Provided herein are compositions and methods for inhibiting cancer cell motility and/or metastasis. In particular embodiments, KBU2046 (or an analog thereof) and one or more additional therapies (e.g., cancer therapies (e.g., hormone therapies and chemotherapies) are provided to inhibit cancer cell motility, inhibit metastasis, and/or treat cancer (e.g., prostate cancer, lung cancer, breast cancer, colon cancer, etc.).

  本文提供了一些用于抑制癌细胞运动和/或转移的组合物和方法。在特定实施例中，提供KBU2046（或其类似物）和一种或多种其他疗法（例如癌症疗法（例如激素疗法和化疗）），以抑制癌细胞运动，抑制转移和/或治疗癌症（例如前列腺癌，肺癌，乳腺癌，结肠癌等）。
• CERAMIDASE INHIBITOR
  申请人：TAKARA BIO INC.

  公开号：EP1707211A1

  公开（公告）日：2006-10-04

  The present invention provides a ceramidase activity inhibitor which inhibits ceramidase activity, specifically neutral/alkaline ceramidase activity, characterized in that the inhibitor comprises, as an active ingredient, a processed product derived from at least one plant selected from the group consisting of plants belonging to Ginkgoaceae, plants belonging to Cucurbitaceae, plants belonging to Rutaceae, plants belonging to Laminariaceae, plants belonging to Myrtaceae and plants belonging to Compositae, and a medicament, a quasi-drug, cosmetics and a food, each comprising the inhibitor.

  本发明提供了一种神经氨酸酶活性抑制剂，它能抑制神经氨酸酶的活性，特别是中性/碱性神经氨酸酶的活性，其特征在于，该抑制剂作为一种活性成分包括一种加工产品，该产品至少来自一种植物，该植物选自银杏科植物、葫芦科植物、芸香科植物、层架科植物、桃金娘科植物和松柏科植物组成的组、葫芦科植物、芸香科植物、层架科植物、桃金娘科植物和松柏科植物中选出的至少一种植物的加工品，以及每种含有该抑制剂的药物、准药物、化妆品和食品。
• Cosmetic composition
  申请人：Cognis IP Management GmbH

  公开号：EP2233128A1

  公开（公告）日：2010-09-29

  The present invention is directed to cosmetic compositions comprising a Calcium citrate and at least one substance of formula (I).

  本发明涉及由柠檬酸钙和至少一种式 (I) 物质组成的化妆品组合物。