2-[(4-Chloro-3-methylphenyl)amino]benzoic acid | 898128-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(4-Chloro-3-methylphenyl)amino]benzoic acid
• 英文别名: 2-(4-chloro-3-methylanilino)benzoic acid
• CAS: 898128-45-5
• 化学式: C₁₄H₁₂ClNO₂
• 分子量: 261.7
• InChiKey: QDNMBJXNLJFNHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF
  申请人：Mickle Travis

  公开号：US20110002990A1

  公开（公告）日：2011-01-06

  The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

  目前描述的技术提供了包含芳基羧酸与羟考酮（吗啡酮-6-酮，4,5-α-环氧-3-甲氧基-17-甲基）化学共轭形成的新型羟考酮前药/组合物，包括苯甲酸酯和杂环芳基羧酸，具有降低滥用羟考酮潜力的特性。该技术还提供了治疗患者的方法、制药工具包和合成本技术共轭物的方法。
• Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof
  申请人：KemPharm, Inc.

  公开号：US20150335759A1

  公开（公告）日：2015-11-26

  The presently described technology provides methods of treating a patient having moderate to severe pain, narcotic or opioid abuse or narcotic or opioid withdrawal. The presently described methods are carried out by comprising administering to the patient a pharmaceutically effective amount of a composition comprising acetaminophen and benzoate-hydrocodone hydrochloride. The composition has reduced side effects when compared with unconjugated hydrocodone.

  目前描述的技术提供了治疗患有中度至严重疼痛、麻醉药或阿片类药物滥用或戒断症状的患者的方法。目前描述的方法是通过向患者施用包含对乙酰氨基酚和苯甲酸盐羟考酮盐酸盐的药物有效量的组合物来实施的。与未结合的羟考酮相比，该组合物具有减少的副作用。
• Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
  申请人：Mickle Travis

  公开号：US20120142719A1

  公开（公告）日：2012-06-07

  The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

  目前描述的技术提供了一种组合物，其中包括芳基羧酸与氢可酮（吗啡酮-6-酮，4,5-α-环氧-3-甲氧基-17-甲基）化学共轭形成的新型氢可酮前药/组合物，包括苯甲酸酯和杂环羧酸，具有降低氢可酮滥用潜力的特点。该技术还提供了治疗患者的方法、药物工具包以及合成该技术共轭物的方法。
• Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Uses Thereof
  申请人：KemPharm, Inc.

  公开号：US20150065536A1

  公开（公告）日：2015-03-05

  The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

  目前所描述的技术提供了化学共轭的芳基羧酸与氢可酮（吗啡酮，4,5-α-环氧-3-甲氧基-17-甲基）形成的新型前药/氢可酮组合物，包括苯甲酸酯和杂环羧酸，其具有降低滥用氢可酮的潜力。本技术还提供了治疗患者的方法、制药套件和合成本技术共轭物的方法。
• Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
  申请人：PHARNEXT

  公开号：US10092554B2

  公开（公告）日：2018-10-09

  The present invention relates to compositions and methods for controlling glycemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies for diabetes and related disorders, based on compositions controlling the blood glucose level.

  本发明涉及控制有需要的哺乳动物血糖的组合物和方法。本发明涉及治疗糖尿病及相关疾病的组合物和方法。更具体地说，本发明涉及基于控制血糖水平的组合物治疗糖尿病及相关疾病的新型疗法或组合疗法。