N'-[(Z)-[1-(3-chlorophenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]-2-nitrobenzohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-[(Z)-[1-(3-chlorophenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]-2-nitrobenzohydrazide
• 化学式: C18H14ClN5O4
• 分子量: 399.8
• InChiKey: IPUHLWLYTSCFLH-GDNBJRDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation
  申请人：Han Hyunsil

  公开号：US20070021448A1

  公开（公告）日：2007-01-25

  The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without or inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.