Benzene-1,3-diamine;hydron;dichloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzene-1,3-diamine;hydron;dichloride
• 英文别名: benzene-1,3-diamine;hydron;dichloride
• 化学式: C6H10Cl2N2
• mdl: MFCD00012975
• 分子量: 181.06
• InChiKey: SVTOYMIYCMHPIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.32
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  4
• 氢受体数：
  2

ADMET

毒理性

• 致癌性证据

没有可用于人体的数据。在动物中致癌性证据不足。总体评估：第3组：该物质对人类的致癌性无法分类。/间苯二胺/

No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans. /M-Phenylenediamine/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。 高铁血红蛋白血症 - 血液中高铁血红蛋白含量增加；该化合物被归类为第二毒性效应 皮肤致敏剂 - 能诱导皮肤过敏反应的制剂。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

立即进行急救：确保已经进行了充分的中和。如果受害者停止呼吸，应开始人工呼吸，最好使用需求阀复苏器、袋阀面罩装置或口袋面罩（按训练使用）。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止窒息。保持受害者安静，并维持正常体温。寻求医疗救助。/有机碱、胺类及相关化合物/

For immediate first aid: Ensure that adequate decontamination has been carried out. If victim is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Obtain medical attention. /Organic bases, amines, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……监测休克，如有必要，进行治疗……预见并治疗癫痫发作……眼睛污染时，立即用清水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……不要使用催吐剂。对于摄入，如果患者能吞咽，有强烈的呕吐反射，且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭……在去污染后，用无菌敷料覆盖皮肤烧伤……/有机碱、胺类及相关化合物/

For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... Monitor for shock and treat if necessary ... Anticipate seizures and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... Cover skin burns with sterile dressings after decontamination ... . /Organic bases, amines, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

/SRP/: 可能形成高铁血红蛋白的物质。

/SRP/: POTENTIAL METHEMOGLOBIN FORMER.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  (Z)-3-[4-[(Z)-2-cyano-3-(3,4,5-trimethoxyphenyl)prop-1-enyl]piperazin-1-yl]-2-[(3,4,5-trimethoxyphenyl)methyl]prop-2-enenitrile 、 Benzene-1,3-diamine;hydron;dichloride 生成 (Z)-3-[3-[[(Z)-2-cyano-3-(3,4,5-trimethoxyphenyl)prop-1-enyl]amino]anilino]-2-[(3,4,5-trimethoxyphenyl)methyl]prop-2-enenitrile
  参考文献：
  名称：

  DAVE, KRISHNA, GOVINDARAM

  摘要：

  DOI：

文献信息

• [EN] DINUCLEAR METAL COMPLEXES COMPRISING CARBENE LIGANDS AND THE USE THEREOF IN OLEDS<br/>[FR] COMPLEXES MÉTALLIQUES BINUCLÉAIRES COMPRENANT DES LIGANDS CARBÈNES ET LEUR UTILISATION DANS DES DIODES ÉLECTROLUMINESCENTES ORGANIQUES (OLED)
  申请人：BASF SE

  公开号：WO2014012972A1

  公开（公告）日：2014-01-23

  The present invention relates to dinuclear metal-carbene complexes comprising a central atom selected from platinum and palladium, where both metal atoms are cyclometalated to the same aromatic group, to OLEDs (Organic Light-Emitting Diodes) which comprise such complexes, to a device selected from the group consisting of illuminating elements, stationary visual display units and mobile visual display units comprising such an OLED, to the use of such a metal-carbene complex in OLEDs, for example as emitter, matrix material, charge transport material and/or charge or exciton blocker.

  本发明涉及双核金属-卡宾配合物，其中中心原子选择自铂和钯，两个金属原子都环金属化到同一芳香基团，以及包括这种配合物的OLEDs（有机发光二极管），选自包括发光元件、固定视觉显示单元和移动视觉显示单元的装置，其中包括这种OLED，以及在OLEDs中使用这种金属-卡宾配合物，例如作为发射体、基质材料、电荷传输材料和/或电荷或激子阻挡剂。
• Hemoregulatory compounds
  申请人：SmithKline Beecham Corporation

  公开号：US06191146B1

  公开（公告）日：2001-02-20

  The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.

  本发明涉及具有血液调节活性的新化合物，可用于刺激造血和治疗病毒、真菌和细菌感染疾病。
• Disubstituted aromatic dianhydrides and polyimides prepared therefrom
  申请人：CIBA-GEIGY AG

  公开号：EP0438382A1

  公开（公告）日：1991-07-24

  Aromatic dianhydrides being substituted in the positions ortho to the bridging moiety, said substituent groups including halogen, alkyl, hydroxy, nitro, cyano, ester, alkoxy, perfluoroalkyl, mercapto and thioester groups, said dianhydrides providing certain beneficial properties to polyimides prepared therefrom.

  芳香族二酐在桥基的正交位置被取代，所述取代基团包括卤素、烷基、羟基、硝基、氰基、酯基、烷氧基、全氟烷基、巯基和硫酯基团，所述二酐可为由此制备的聚酰亚胺提供某些有益特性。
• MEDICAL DEVICE AND METHOD OF MANUFACTURING SAME
  申请人：Toray Industries, Inc.

  公开号：EP3858391A1

  公开（公告）日：2021-08-04

  A medical device including a substrate and a hydrophilic polymer layer and satisfying the following conditions: (1) that the hydrophilic polymer layer is on at least a part of the substrate; (2) that the hydrophilic polymer layer contains: a hydrophilic polymer having an acidic group; and a compound having an acidic group and a ring structure; and (3) that a time during which a liquid film is retained on the surface of the medical device (a liquid film retention time) is 10 seconds or more after the medical device is stationarily immersed in a phosphate buffer solution, pulled up from the phosphate buffer solution, and retained in the air. The present invention provides a medical device in which a surface of a substrate is hydrophilized, and a method for manufacturing same by a simple method.

  一种医疗设备，包括基底和亲水聚合物层，并满足以下条件：(1) 亲水聚合物层至少位于基底的一部分上；(2) 亲水聚合物层包含：具有酸性基团的亲水聚合物；以及具有酸性基团和环状结构的化合物；以及(3) 液膜在医疗设备表面保留的时间（液膜保留时间）：具有酸性基团的亲水性聚合物；以及具有酸性基团和环状结构的化合物；以及 (3) 在将医疗设备固定浸入磷酸盐缓冲溶液、从磷酸盐缓冲溶液中拉出并保留在空气中后，液膜保留在医疗设备表面的时间（液膜保留时间）为 10 秒或更长。本发明提供了一种基底表面亲水化的医疗器械，以及一种通过简单方法制造该医疗器械的方法。
• Heat-sensitive recording material
  申请人：PAPIERFABRIK AUGUST KOEHLER SE

  公开号：US11084307B2

  公开（公告）日：2021-08-10

  The invention relates to a compound of the formula (I) Ar(NHSO2Ar1)l(SO2NHAr1)m(NHC(O)NHAr2)n (I), wherein l and m independently of one another are 0, 1, 2, 3, and/or 4 and the sum of l+m is equal to or more than 1, n is 2, 3, 4, or 5, Ar is a benzol group which is substituted (l+m+n) times, Ar1 is an unsubstituted or substituted aromatic group, and Ar2 is an unsubstituted or substituted phenyl group or a benzoyl group. The invention also relates to a heat-sensitive recording material comprising a carrier substrate and a heat-sensitive color-forming layer which contains at least one color former and at least said color developer.

  本发明涉及一种式(I)Ar(NHSO2Ar1)l(SO2NHAr1)m(NHC(O)NHAr2)n (I)的化合物，其中 l 和 m 相互独立地为 0、1、2、3 和/或 4，且 l+m 之和等于或大于 1、n是2、3、4或5，Ar是被取代（l+m+n）次的苯酚类基团，Ar1是未取代或取代的芳香族基团，Ar2是未取代或取代的苯基或苯甲酰基团。本发明还涉及一种热敏记录材料，包括载体基底和热敏显色层，热敏显色层包含至少一种显色剂和至少所述显色剂。

表征谱图