(+/-)-6-morpholino-4,4-diphenyl-heptan-3-one; hydrochloride | 20874-24-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-6-morpholino-4,4-diphenyl-heptan-3-one; hydrochloride
• 英文别名: (+/-)-6-Morpholino-4,4-diphenyl-heptan-3-on; Hydrochlorid；heptone；hydron;6-morpholin-4-yl-4,4-diphenylheptan-3-one;chloride
• CAS: 20874-24-2
• 化学式: C₂₃H₂₉NO₂*ClH
• 分子量: 387.95
• InChiKey: QGUPBYVADAJUNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.48
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+/-)-6-morpholino-4,4-diphenyl-heptan-3-one; hydrochloride 在 水 、 铂 作用下， 生成 6-morpholino-4,4-diphenyl-heptan-3-ol
  参考文献：
  名称：

  与a酮有关的镇痛性甲醇和酯。

  摘要：

  DOI：

  10.1021/ja01169a016

文献信息

• Dihydropyrimidinone derivatives
  申请人：KING SAUD UNIVERSITY

  公开号：US10111873B1

  公开（公告）日：2018-10-30

  A dihydropyrimidinone derivative having a chemical structure according to Formula 1: wherein Z is selected from N and O; X is selected from O and S; and R represents aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the substituted aryl or substituted heteroaryl have one or more substituents selected from halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, hydroxyl, alkylthio, alkylamino, heteroaryl, aryloxy, haloaryloxy, arylthio, arylamino, and pharmaceutically acceptable salts thereof.

  一种二氢嘧啶酮衍生物，其化学结构如公式1所示：其中Z选自N和O；X选自O和S；而R代表芳基，取代芳基，杂环芳基或取代杂环芳基，其中取代芳基或取代杂环芳基具有一个或多个取代基，所述取代基选自卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，硝基，羟基，烷硫基，烷基氨基，杂环芳基，芳基氧基，卤代芳基氧基，芳基硫基，芳基氨基和其药学上可接受的盐。
• Catalyst compositions containing a trialkyl aluminium co-catalyst and the use for the polymerization of olefins
  申请人：EXXON RESEARCH AND ENGINEERING COMPANY

  公开号：EP0004481A2

  公开（公告）日：1979-10-03

  A catalyst suitable for alpha olefin polymerization comprises (a) a Group IVA to VIII transition metal chloride or bromide on a support, e.g. TiCl4 on MgCl2, (b) an alkyl metal compound having at least one group where R" is methyl or ethyl and R''' is a C1 to C10 alkyl group, e.g. neopentyl Al(C2H5)2 and (c) a Lewis base e.g. ethyl benzoate.

  适用于α-烯烃聚合的催化剂包括 (a) 在载体上的第 IVA 至 VIII 族过渡金属氯化物或溴化物，例如氯化镁上的 TiCl4、 (b) 烷基金属化合物，其中至少有一个基团 其中 R "为甲基或乙基，R'''为 C1 至 C10 烷基，如新戊基 Al(C2H5)2 和 (c) 路易斯碱，如苯甲酸乙酯。
• Halogenated bisphenol a ether flame retardant for ABS polymers
  申请人：GREAT LAKES CHEMICAL CORPORATION

  公开号：EP0192885A2

  公开（公告）日：1986-09-03

  There is disclosed a flame-retardant composition comprising an acrylonitrile-butadiene-styrene copolymer and a sufficient amount of bis (2, 4, 6-tribromophenoxy-ethyl) -tetrabromobisphenol A ether to confer flame-retardant properties on the composition.

  本发明公开了一种阻燃组合物，该组合物由丙烯腈-丁二烯-苯乙烯共聚物和足量的双（2，4，6-三溴苯氧基-乙基）-四溴双酚 A 醚组成，以赋予组合物阻燃特性。
• Phenylpyrimidine derivatives, process for preparing the same, liquid crystal compositions containing said derivatives as active ingredient, and liquid crystal elements using such compositions
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0435632A2

  公开（公告）日：1991-07-03

  Disdosed in this invention are the phenylpyrimidine derivatives represented by the general formula I : the alcohols represented by the formula: usable as starting material for the preparation of the phenyipyrimidine derivatives, and the processes for preparing such derivatives. The phenylpyrimidine derivatives of the formula I according to the present invention have very excellent properties as a liquid crystal compound and can be utilized effectively for the production of liquid crystal elements.

  本发明中所使用的是通式 I 所代表的苯基嘧啶衍生物： 式所代表的醇： 可用作制备苯基嘧啶衍生物的起始原料，以及制备此类衍生物的工艺。根据本发明，式 I 的苯基嘧啶衍生物作为液晶化合物具有非常优异的性能，可有效地用于生产液晶元件。
• A polypeptide capable of interacting with thrombin
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0474273A2

  公开（公告）日：1992-03-11

  Disclosed is a substantially pure polypeptide having a specific amino acid sequence containing (a) an amino acid residue selected from the group consisting of Asp, Glu and Gla wherein Gla represents a γ-carboxyglutamic acid residue or (b) a peptide or polypeptide residue consisting of at least two amino acid residues selected from Asp, Glu and Gla, wherein the above-mentioned at least two amino acid residues are all the same or combinations of the Asp, Glu and Gla. The polypeptide is capable of interacting with thrombin to form a binding therebetween, thereby exhibiting an activity to inhibit the blood coagulation and platelet aggregation by thrombin and/or an activity to promote the thrombin-catalyzed activation of protein C. This novel polypeptide has a low molecular weight so that it is suitable for oral or nasal administration.

  本发明公开了一种具有特定氨基酸序列的基本纯多肽，该氨基酸序列含有(a)选自Asp、Glu和Gla组成的组的氨基酸残基，其中Gla代表γ-羧基谷氨酸残基；或(b)由至少两个选自Asp、Glu和Gla的氨基酸残基组成的肽或多肽残基，其中上述至少两个氨基酸残基均为相同的或Asp、Glu和Gla的组合。这种多肽能够与凝血酶相互作用，在两者之间形成结合，从而表现出抑制凝血酶的血液凝固和血小板聚集的活性和/或促进凝血酶催化的蛋白 C 活化的活性。