O-去甲基文拉法辛二聚体 | 1187545-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: O-去甲基文拉法辛二聚体
• 英文名称: 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-2-({5-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-2-hydroxyphenyl}methyl)phenol
• 英文别名: O-Desmethyl Venlafaxine Dimer；4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-2-[[5-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-2-hydroxyphenyl]methyl]phenol
• CAS: 1187545-62-5
• 化学式: C₃₃H₅₀N₂O₄
• 分子量: 538.771
• InChiKey: FBAYPDCBRZOERJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Processes for the preparation of odesmethylvenlafaxine, free from its dimer impurities
  申请人：Niddam-Hildesheim Valarie

  公开号：US20090234020A1

  公开（公告）日：2009-09-17

  The present invention provides isolated O-desmethylvenlafaxine impurities ODV-Dimer and ODV-N-Dimer, their use as a reference marker and reference standard, and a process for the preparation of O-desmethylvenlafaxine free from said impurities

  本发明提供了分离的O-去甲基文拉法辛杂质ODV-Dimer和ODV-N-Dimer，它们作为参考标记和参考标准的用途，以及一种制备不含该杂质的O-去甲基文拉法辛的方法。
• PROCESSES FOR THE PREPARATION OF O-DESMETHYLVENLAFAXINE, FREE FROM ITS DIMER IMPURITIES
  申请人：Teva Pharmaceutical Industries Ltd.

  公开号：EP2252574A1

  公开（公告）日：2010-11-24
• [EN] PROCESSES FOR THE PREPARATION OF O-DESMETHYLVENLAFAXINE, FREE FROM ITS DIMER IMPURITIES<br/>[FR] PROCÉDÉS DE PRÉPARATION DE LA O-DESMÉTHYLVENLAFAXINE, EXEMPTE DE SES IMPURETÉS DIMÈRES
  申请人：TEVA PHARMA

  公开号：WO2009151494A1

  公开（公告）日：2009-12-17

  The present invention provides isolated O-desmethylvenlafaxine impurities ODV-Dimer and ODV-N-Dimer, their use as a reference marker and reference standard, and a process for the preparation of O-desmethylvenlafaxine free from said impurities.