Acid blue 9 ammonium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Acid blue 9 ammonium
• 英文别名: azane;3-[[N-ethyl-4-[[4-[ethyl-[(3-sulfophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]-(2-sulfophenyl)methyl]anilino]methyl]benzenesulfonate
• 化学式: C37H42N4O9S3
• 分子量: 783.0
• InChiKey: HMEKVHWROSNWPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.78
• 重原子数：
  53
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  205
• 氢给体数：
  2
• 氢受体数：
  10

ADMET

毒理性

• 致癌性证据

没有关于人类的数据。动物致癌性的证据有限。总体评估：第3组：该物质对人类致癌性无法分类。

No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

所有幼崽从4天大开始人工饲养。含有食品色素（D）或不加色素（N）的液体饮食被注入6-羟基多巴胺（6-OHDA）和假手术处理的幼崽中。在所有测试的年龄阶段，接受食品色素的幼崽的活动性显著高于不接受食品色素的幼崽，这一效果在6-OHDA（T）和假手术处理的幼崽（V）中观察到。接受食品色素处理的幼崽在28天大时在穿梭箱中表现出避免反应受损。VD和TN幼崽的避免反应性能比VN幼崽降低了超过100%。食品色素及其代谢物可能对发育中的大鼠幼崽的行为产生有害影响。

ALL PUPS WERE ARTIFICIALLY REARED FROM 4 DAYS OF AGE. LIQ DIET CONTAINING FOOD DYES (D) OR NO COLORINGS (N) WAS INFUSED INTO 6-HYDROXYDOPAMINE (6-OHDA) & SHAM-TREATED PUPS. PUPS RECEIVING FOOD DYES WERE SIGNIFICANTLY MORE ACTIVE THAN COMPARABLE PUPS NOT RECEIVING FOOD DYES AT ALL AGES TESTED, AN EFFECT OBSERVED IN 6-OHDA (T) & SHAM-TREATED PUPS (V). PUPS TREATED WITH FOOD DYES EXHIBITED AN IMPAIRED AVOIDANCE PERFORMANCE IN SHUTTLE BOX AT 28 DAYS OF AGE. VD & TN PUPS DISPLAYED MORE THAN A 100% IMPAIRMENT IN AVOIDANCE PERFORMANCE COMPARED WITH VN PUPS. FOOD DYES &/OR THEIR METABOLITES MAY EXERT DELETERIOUS EFFECTS ON THE BEHAVIOR OF DEVELOPING RAT PUPS.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

食品色素，包括亮蓝色素，在添加到基础净化、低纤维饮食（25%酪蛋白-蔗糖）的5%水平时，会导致大鼠严重生长迟缓。

FOOD COLORS INCLUDING BRILLIANT BLUE CAUSED SEVERE GROWTH RETARDATION IN RATS WHEN ADDED TO A BASAL PURIFIED, LOW-FIBER DIET (25% CASEIN-SUCROSE) AT 5% LEVEL.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

肾脏肿瘤在20只斯普拉格-道利大鼠中的1只观察到，该大鼠口服了一次性剂量的色指数酸性蓝9。89只对照组中的1只也有肿瘤。

CARCINOMA OF THE KIDNEY WAS SEEN IN 1 OF 20 SPRAGUE-DAWLEY RATS ADMIN A SINGLE ORAL DOSE OF COLOR INDEX ACID BLUE 9. 1 OF 89 CONTROLS ALSO HAD A CARCINOMA.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

... 在兔眼测试中无损害。

... Not damaging in rabbit eye test.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在给予雄性或雌性大鼠一次口服亮蓝色FCF剂量，无论是30微克/千克还是3毫克/千克，实质上所有的剂量在72小时内未发生改变，通过粪便排出。在大鼠接受(14)C标记色素处理之前，先用未标记的亮蓝色FCF饮食（30毫克/千克/天）预处理雄性大鼠21天，对此途径的排泄或消除所有标记所需的时间没有影响。同样，雄性小鼠和豚鼠也通过粪便排出了单次口服亮蓝色FCF的剂量。通过对隔离的小肠环进行的研究，确认了所有三种调查物种的小肠中标记染料的吸收和代谢缺失。给予(14)C标记亮蓝色FCF的怀孕大鼠的胎儿没有摄取放射性物质。

FOLLOWING ADMIN OF A SINGLE ORAL DOSE OF BRILLIANT BLUE FCF AT EITHER 30 MUG/KG OR 3 MG/KG TO MALE OR FEMALE RATS, SUBSTANTIALLY ALL OF THE DOSE WAS EXCRETED UNCHANGED IN FECES WITHIN 72 HR. PRETREATING MALE RATS WITH UNLABELED BRILLIANT BLUE FCF IN THE DIET (30 MG/KG/DAY) FOR 21 DAYS PRIOR TO DOSING WITH (14)C-LABELED COLORING HAD NO EFFECT ON ROUTE OF EXCRETION OR THE TIME TAKEN TO ELIMINATE ALL OF THE LABEL. SIMILARLY, MALE MICE & GUINEA PIGS EXCRETED IN THE FECES ALL OF A SINGLE ORAL DOSE OF BRILLIANT FCF. THE LACK OF ABSORPTION & METABOLISM OF THE LABELED DYE IN GI TRACT OF ALL 3 SPECIES INVESTIGATED WAS CONFIRMED BY STUDIES USING ISOLATED LOOPS OF SMALL INTESTINE. NO RADIOACTIVITY WAS TAKEN UP BY THE FETUSES OF PREGNANT RATS GIVEN (14)C-LABELED BRILLIANT BLUE FCF.

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• Bleach activators and method for the production thereof
  申请人：Pegelow Ulrich

  公开号：US20070197416A1

  公开（公告）日：2007-08-23

  Bleach activator compatibility with bleach-sensitive dyestuffs can be improved in accordance with various embodiments of the invention including methods for producing coated bleach activators which methods comprise: granulating at least one bleach activator with at least one binding agent to form a granulated material; coating the granulated material with a solution or dispersion of at least one complexing agent to form a coated granulated material; and drying the coated granulated material.

  漂白剂激活剂与对漂白剂敏感的染料的相容性可以根据发明的各种实施方式进行改善，包括生产涂层漂白剂激活剂的方法，该方法包括：将至少一种漂白剂激活剂与至少一种粘合剂颗粒化以形成颗粒材料；用至少一种络合剂的溶液或分散液对颗粒材料进行涂层，以形成涂层颗粒材料；并干燥涂层颗粒材料。
• Emulgatorfreie kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Hydroxybenphenonen
  申请人：Beiersdorf AG

  公开号：EP1310235A2

  公开（公告）日：2003-05-14

  Pickering-Emulsionen, welche feindisperse Systeme vom Typ Wasser-in-Öl oder Öl-in-Wasser darstellen, enthaltend (1) eine Ölphase, (2) eine Wasserphase, (3) mindestens einen Typ mikrofeiner Partikel, die a) eine mittlere Partikelgröße von weniger als 200 nm haben, die b) sowohl hydrophile als auch lipophile Eigenschaften zeigen, welche also amphiphilen Charakter besitzen und sowohl in Wasser als auch in Öl dispergierbar sind und die c) gegebenenfalls oberflächlich beschichtet sind, (4) mindestens ein Hydroxybenzophenon und (5) höchstens 1 Gew.-% eines oder mehrerer Emulgatoren.

  皮克林乳液是油包水或水包油型的精细分散体系，含有 (1) 油相 (2) 水相 (3) 至少一种微细颗粒，其中 a) 平均粒径小于 200 纳米，且 b) 同时具有亲水性和亲油性，即具有两亲性，可分散在水和油中，以及 c) 可选择表面涂层、 (4) 至少一种羟基二苯甲酮，以及 (5) 按重量计不超过 1%的一种或多种乳化剂。
• Oral care compositions with increased whitening efficacy
  申请人：Colgate-Palmolive Company

  公开号：US10668005B2

  公开（公告）日：2020-06-02

  An oral care composition and method for whitening teeth is disclosed. The oral care composition includes an orally acceptable vehicle, a blue dye and/or blue pigment having a blue to blue-violet color with a hue angle in the CIELAB system from about 200 to about 320 degrees, and a phosphate/acrylate copolymer.

  本发明公开了一种用于美白牙齿的口腔护理组合物和方法。 该口腔护理组合物包括一种口服可接受载体、一种蓝色染料和/或蓝色颜料（其颜色为蓝色至蓝紫色，在 CIELAB 系统中色调角约为 200 至约 320 度）以及一种磷酸盐/丙烯酸酯共聚物。
• Inks exhibiting expanded color-space characteristics for water-based printing
  申请人：——

  公开号：US20020040659A1

  公开（公告）日：2002-04-11

  Novel magenta and cyan colorants for utilization within water-based inks are provided which exhibit improved chromatic properties. In particular, such colorants provide magenta or cyan colorations that exhibit increased color space characteristics, high water solubility, excellent compatability with impurities, and correspondingly cost-effectiveness for flexographic printing procedures. The methods of utilizing such colorants within flexographic printing processes are also encompassed within the invention.

  本发明提供了用于水基油墨的新型品红和青色着色剂，这些着色剂具有更好的色度特性。特别是，这种着色剂提供的品红或青色着色剂具有更高的色域特性、高水溶性、与杂质的良好相容性，以及相应的柔版印刷工艺成本效益。在柔版印刷工艺中使用此类着色剂的方法也包含在本发明中。
• Absorbent article having a fever indicator
  申请人：The Procter & Gamble Company

  公开号：US20030014025A1

  公开（公告）日：2003-01-16

  A wearable article including a fever indicator disposed on at least a portion of the article for indicating the body temperature of a wearer. The fever indicator may be used in conjunction with a disposable absorbent article and provides a signal indicating qualitative or quantitative information about the body temperature of the wearer based on the temperature of the wearer's urine.

  一种可穿戴物品，包括一个设置在该物品至少一部分上的发热指示器，用于显示穿戴者的体温。发热指示器可与一次性吸收用品结合使用，并根据佩戴者的尿液温度提供信号，显示佩戴者体温的定性或定量信息。