Alphazurine | 2650-18-2; 3844-45-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Alphazurine
• 英文别名: ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(2-sulfophenyl)methylidene]cyclohexa-2,5-dien-1-ylidene]-[(3-sulfophenyl)methyl]azanium
• CAS: 2650-18-2; 3844-45-9
• 化学式: C37H37N2O9S3+
• 分子量: 749.9
• InChiKey: CTRXDTYTAAKVSM-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  51
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  195
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• COLORING AGENTS AND METHODS OF USE THEREOF
  申请人：Living Proof, Inc.

  公开号：US20160106648A1

  公开（公告）日：2016-04-21

  Dyes, compositions comprising dyes and methods for using the same are provided.

  染料、包含染料的组合物以及使用这些染料的方法。
• PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE RESIN FILM USING THE SAME AND COLOR FILTER
  申请人：SAMSUNG SDI CO., LTD.

  公开号：US20170108773A1

  公开（公告）日：2017-04-20

  A photosensitive resin composition, a photosensitive resin film, and a color filter, the composition including a binder resin; a dye consisting of a cation and an anion; a photopolymerizable compound; a photopolymerization initiator, and a solvent, wherein the dye is included in an amount of about 15 wt % to about 40 wt % based on a total weight of a photosensitive resin composition, and wherein the cation is represented by Chemical Formula 1:

  一种光敏树脂组合物、光敏树脂膜和彩色滤光片，该组合物包括粘合树脂；由阳离子和阴离子组成的染料；光聚合化合物；光聚合引发剂和溶剂，其中染料的含量约为光敏树脂组合物总重量的15wt％至40wt％，其中阳离子由化学式1表示：
• Methods and compositions for treating alcohol use disorders
  申请人：Sanna Pietro Paolo

  公开号：US10039772B2

  公开（公告）日：2018-08-07

  Disclosed are methods and compositions for treating alcohol dependence by administration to a patient of an inhibitor of 11β-hydroxysteroid dehydrogenases (11β-HSD) to modulate glucocorticoid effects. One such compound is the 11β-HSD inhibitor carbenoxolone (18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively employed in the clinic for the treatment of gastritis and peptic ulcer. Carbenoxolone is active on both 11β-HSD1 and 2 isoforms. Here, carbenoxolone is surprisingly shown to reduce both baseline and excessive drinking in rats and mice. The carbenoxolone diastereomer 18α-glycyrrhetinic acid 3β-O-hemisuccinate (αCBX), which the applicants discovered to be selective for 11β-HSD2, was also effective in reducing alcohol drinking in mice. Thus, 11β-HSD inhibitors are a new class of candidate alcohol abuse medications and existing 11β-HSD inhibitor drugs may be re-purposed for alcohol abuse treatment.

  本发明公开了通过向患者施用 11β-羟基类固醇脱氢酶（11β-HSD）抑制剂以调节糖皮质激素作用来治疗酒精依赖症的方法和组合物。其中一种化合物是 11β-HSD 抑制剂卡本诺酮（18β-甘草次酸 3β-O-hemisuccinate ），临床上已广泛用于治疗胃炎和消化性溃疡。卡贝诺酮对 11β-HSD1 和 2 同工酶均有活性。令人惊讶的是，羧甲诺龙在大鼠和小鼠体内可减少基线饮酒量和过量饮酒量。申请人发现，羧诺龙的非对映异构体 18α-甘草次酸 3β-O-hemisuccinate (αCBX)对 11β-HSD2 具有选择性，也能有效减少小鼠的饮酒量。因此，11β-HSD 抑制剂是一类新的候选酗酒药物，现有的 11β-HSD 抑制剂药物可重新用于酗酒治疗。
• Oral care composition comprising bleaching agent
  申请人：ROHM AND HAAS COMPANY

  公开号：US10058492B2

  公开（公告）日：2018-08-28

  The disclosed invention relates to a composition for delivery of a bleaching agent to an oral cavity. The composition is stable to environmental storage conditions, but upon subjection to highly aqueous conditions, releases the bleaching agent for use.

  本发明涉及一种向口腔输送漂白剂的组合物。该组合物对环境储存条件稳定，但在高水性条件下会释放出漂白剂以供使用。
• Skin care compositions containing light diffuser polymeric beads
  申请人：ROHM AND HAAS COMPANY

  公开号：US10342753B2

  公开（公告）日：2019-07-09

  Disclosed are skin care compositions containing refractive polymeric particles. The composition improves the appearance of skin but reducing gloss without a noticeable presence on the skin surface.

  本发明公开了含有折光聚合物颗粒的护肤组合物。该组合物可改善皮肤外观，但会降低光泽度，且不会明显出现在皮肤表面。