disodium;3-[[6-(3-carboxylato-2,4,6-triiodoanilino)-6-oxohexanoyl]amino]-2,4,6-triiodobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: disodium;3-[[6-(3-carboxylato-2,4,6-triiodoanilino)-6-oxohexanoyl]amino]-2,4,6-triiodobenzoate
• 化学式: C20H12I6N2Na2O6
• 分子量: 1183.7
• InChiKey: SIZXNBZGPPPFHM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.81
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] Novel 7-Dehydrocholesterol Derivatives and Methods Using Same<br/>[FR] NOUVEUX DÉRIVÉS DE 7-DÉSHYDROCHOLESTÉROL ET PROCÉDÉS LES UTILISANT
  申请人：WOMEN & INFANTS HOSPITAL OF RHODE ISLAND

  公开号：WO2015157262A1

  公开（公告）日：2015-10-15

  The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

  本发明在某些方面提供了新颖的7-去氢胆固醇（7DHC）衍生物，这些衍生物在治疗或预防癌症以及治疗或预防受试者中的不受控制的血管生成方面是有用的。在本发明的某些实施例中，受试者是人类。在其他方面，本发明提供了制备本发明化合物的方法，或其盐或溶剂。
• X-RAY CONTRAST MEDIUM CONTAINING LIPOSOME AND METHOD FOR PREPARATION THEREOF
  申请人：Konica Minolta Medical & Graphic, Inc.

  公开号：EP1679084A1

  公开（公告）日：2006-07-12

  A radiographic contrast medium is disclosed, comprising liposomes having a narrow vesicle size distribution and comprising a lipid membrane containing a polyalkylene oxide group-containing compound and/or sterols, and the liposomes enclosing a water-soluble nonionic iodine compound. The liposomes which enclose a water phase inside the lipid membrane are dispersed in an aqueous medium, and preferably, both of the water phase and the aqueous medium contain the iodine compound and an additive and each of an iodine compound concentration and an additive concentration is substantially the same in both of the water phase and the aqueous medium, in which the weight ratio of the iodine compound to the lipid membrane is 1 to 10. The contrast medium is prepared by the supercritical carbon dioxide method and therefore, is substantially free of a toxic solvent such as a chlorine-containing solvent.

  本发明公开了一种射线造影剂，它由具有窄囊泡尺寸分布的脂质体组成，脂质体由含有聚环氧烷基化合物和/或甾醇的脂膜组成，脂质体中含有水溶性非离子碘化合物。脂膜内含有水相的脂质体分散在水介质中，最好水相和水介质都含有碘化合物和添加剂，且水相和水介质中碘化合物浓度和添加剂浓度基本相同，其中碘化合物与脂膜的重量比为 1 比 10。对比介质是用超临界二氧化碳法制备的，因此基本上不含有毒溶剂，如含氯溶剂。
• LIPOSOME-CONTAINING X-RAY RADIOPAQUE DYE AND PROCESS FOR PRODUCING THE SAME
  申请人：Konica Minolta Medical & Graphic, Inc.

  公开号：EP1772156A1

  公开（公告）日：2007-04-11

  A liposome-containing radiographic contrast medium comprising a water-soluble iodine compound contained in a water phase inside and outside lipid membranes is disclosed. The liposomes are produced by mixing lipid membrane components for constituting lipid membranes with carbon dioxide of a supercritical of subcritical state in the presence of at least one compound containing a hydroxyl or polyalkylene oxide group. The obtained radiographic contrast medium does not contain any toxic solvents such as chlorinated solvents, so that high safety can be ensured.

  本发明公开了一种含脂质体的放射造影剂，该造影剂由一种水溶性碘化合物组成，该碘化合物包含在脂质膜内外的水相中。这种脂质体是在至少一种含有羟基或聚氧化亚烷基的化合物存在下，通过将构成脂质膜的脂质膜成分与超临界或亚临界状态的二氧化碳混合制成的。所获得的射线造影剂不含任何有毒溶剂，如氯化溶剂，因此可确保高度安全性。
• 7-dehydrocholesterol derivatives and methods using same
  申请人：University of Rochester

  公开号：US10683324B2

  公开（公告）日：2020-06-16

  The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

  本发明在某些方面提供了新型 7-脱氢胆固醇（7DHC）衍生物，可用于治疗或预防癌症，以及治疗或预防受试者体内不受控制的血管生成。在本发明的某些实施方案中，受试者是人类。在其他方面，本发明提供了一种制备本发明化合物或其盐或溶液的方法。
• Compositions and methods for targeting cancers
  申请人：YALE UNIVERSITY

  公开号：US11311538B2

  公开（公告）日：2022-04-26

  In various aspects and embodiments the invention provides a method of treating or preventing a cancer in a mammalian subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of at least one compound selected from the group consisting of a DNA repair inhibitor, a DNA strand break repair inhibitor, and a homologous recombination (HR) repair inhibitor, wherein cells in the cancer comprise a fumarate hydratase (FH) and/or succinate dehydrogenase (SDH) mutation.

  在不同方面和实施方案中，本发明提供了一种治疗或预防有需要的哺乳动物癌症的方法，该方法包括向受试者施用治疗有效量的至少一种选自DNA修复抑制剂、DNA链断裂修复抑制剂和同源重组（HR）修复抑制剂组成的组的化合物，其中癌症细胞包含富马酸氢化酶（FH）和/或琥珀酸脱氢酶（SDH）突变。