guinia green B | 4680-78-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: guinia green B
• 英文别名: guinea green B；Acid Green；sodium;3-[[N-ethyl-4-[[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]-phenylmethyl]anilino]methyl]benzenesulfonate
• CAS: 4680-78-8
• 化学式: C₃₇H₃₅N₂O₆S₂*Na
• 分子量: 690.816
• InChiKey: XKTMIJODWOEBKO-UHFFFAOYSA-M

物化性质

• 熔点：
  255 °C (dec.) (lit.)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• 物理描述：
  C.i. acid green 3 appears as a dull dark green powder. Used as a dye for silk or wool and biological stains.
• 颜色/状态：
  A dull, dark green powder or bright crystalline solid
• 蒸汽压力：
  7.2X10-39 mm Hg at 25 °C (est)
• 分解：
  When heated to decomposition it emits very toxic fumes of /sulfur and nitrogen oxides as well as sodium monoxide/.

计算性质

• 辛醇/水分配系数(LogP)：
  3.13
• 重原子数：
  48
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  137
• 氢给体数：
  0
• 氢受体数：
  7

ADMET

毒理性

• 致癌性证据

没有关于人类的数据。动物致癌性的证据有限。总体评估：第3组：该物质对人类致癌性无法分类。

No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌剂：吉纳绿B

IARC Carcinogenic Agent:Guinea Green B

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构（IARC）致癌物分类：第3组：无法归类其对人类致癌性

IARC Carcinogenic Classes:Group 3: Not classifiable as to its carcinogenicity to humans

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构专著：第16卷（1978年）一些芳香胺及其相关硝基化合物 - 染发剂、着色剂和杂项工业化学品

IARC Monographs:Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals

来源:International Agency for Research on Cancer (IARC)

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者呕吐，让患者身体前倾或将其置于左侧（如果可能，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗救助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在大鼠口服给药的研究中发现，只有少量染料（小于5%）被吸收并在胆汁中未改变地排出。在大鼠静脉注射后，大约75%的染料在4小时内通过胆汁排出。

Studies in rats involving oral administration showed that only small amounts of the dye (< 5%) are absorbed and excreted unchanged in the bile. Following its iv injection in rats, about 75% of the dye was excreted in the bile within 4 hr.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  3204120000

反应信息

• 作为反应物：
  描述：

  alphazurine A 、 guinia green B 、 sodium;3-methyl-4-[(2Z)-2-(2-oxonaphthalen-1-ylidene)hydrazinyl]benzenesulfonate 、 disodium;(3Z)-5-acetamido-4-oxo-3-(phenylhydrazinylidene)naphthalene-2,7-disulfonate 、 disodium;(3Z)-5-acetamido-3-[(4-acetamidophenyl)hydrazinylidene]-4-oxonaphthalene-2,7-disulfonate 、 disodium;2,5-dichloro-4-[3-methyl-5-oxo-4-[(4-sulfonatophenyl)diazenyl]-4H-pyrazol-1-yl]benzenesulfonate 生成 disodium;8-anilino-5-[[4-[(5-sulfonatonaphthalen-1-yl)diazenyl]naphthalen-1-yl]diazenyl]naphthalene-1-sulfonate
  参考文献：
  名称：

  Colorant-containing curable negative-type composition, color filter using the composition, and method of manufacturing the same

  摘要：

  本发明提供了一种含颜料的可固化负型组合物，该组合物至少包含颜料、交联剂和光敏剂，并满足以下条件（1），与所述组合物进一步包含粘合剂的各组分的质量相关，并满足以下条件（2），与所述组合物不包含粘合剂的各组分的质量相关：条件（1）：其中粘合剂的质量>0，0.45≤颜料的质量/[颜料的质量+交联剂的质量+光敏剂的质量+粘合剂的质量]<1.0且2<[交联剂的质量/粘合剂的质量]；条件（2）：其中粘合剂的质量=0，0.45≤颜料的质量/[颜料的质量+交联剂的质量+光敏剂的质量]<1.0。

  公开号：

  US07763401B2

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Hydrogen peroxide and peracetic acid indicators and methods
  申请人：3M Innovative Properties Company

  公开号：US20030194346A1

  公开（公告）日：2003-10-16

  The present invention provides a hydrogen peroxide indicator and a peracetic acid indicator that include a substrate on which is disposed an indicator composition that includes at least one of a select group of colorants and a transition metal salt. As a result of exposure to hydrogen peroxide and/or peracetic acid, the colorants change color, and even become colorless, thereby providing an indication of the presence of hydrogen peroxide and/or peracetic acid.

  本发明提供了一种过氧化氢指示剂和过醋酸指示剂，其包括一个基质，该基质上设有一个指示剂组成物，该指示剂组成物包括至少一种选定的颜料和过渡金属盐。由于接触到过氧化氢和/或过醋酸，颜料会改变颜色，甚至变得无色，从而提供过氧化氢和/或过醋酸的存在指示。
• HYDROGEN PEROXIDE AND PERACETIC ACID INDICATORS AND METHODS
  申请人：READ David M.

  公开号：US20100124784A1

  公开（公告）日：2010-05-20

  The present invention provides a hydrogen peroxide indicator and a peracetic acid indicator that include a substrate on which is disposed an indicator composition that includes at least one of a select group of colorants and a transition metal salt. As a result of exposure to hydrogen peroxide and/or peracetic acid, the colorants change color, and even become colorless, thereby providing an indication of the presence of hydrogen peroxide and/or peracetic acid.

  本发明提供了一种过氧化氢指示剂和一种过醋酸指示剂，其包括一个基质，在基质上设置有一个指示剂组合物，该组合物包括至少一种选定的颜料和过渡金属盐。由于暴露于过氧化氢和/或过醋酸中，颜料会改变颜色，甚至变得无色，从而提供过氧化氢和/或过醋酸存在的指示。
• Enzyme containing denture cleansers and method of use
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0258186A2

  公开（公告）日：1988-03-02

  Enzyme containing denture cleanser tablets utilizing effective plaque and stain removal proteolytic enzymes prepared by the fermentation of Bacillus licheniformis and a method for cleansing dentures employing the tablets are disclosed.

  本发明公开了利用地衣芽孢杆菌发酵制备的有效去除牙菌斑和污渍的蛋白水解酶的含酶义齿清洁剂片剂，以及使用该片剂清洁义齿的方法。