1-[10-[3-(Dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydron;chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 1-[10-[3-(Dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydron;chloride
• 化学式: C20H25ClN2OS
• 分子量: 376.9
• InChiKey: ZFWVWZODBGTOIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.26
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  48.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[10-[3-(Dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydron;chloride 生成 Zr(NO3)4 (propionylpromazine phosphate)
  参考文献：
  名称：

  KESHAVAN, B.;SEETHARAMAPPA, J., SYNTH. AND REACT. INORG. AND METAL ORG. CHEM., 18,(1988) N 5, C. 449-456

  摘要：

  DOI：

文献信息

• KESHAVAN, B.;SEETHARAMAPPA, J., SYNTH. AND REACT. INORG. AND METAL ORG. CHEM., 18,(1988) N 5, C. 449-456
  作者：KESHAVAN, B.、SEETHARAMAPPA, J.

  DOI：——

  日期：——
• DIFFERENTIATED CELL POPULATION OF ENDOTHELIAL CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS, COMPOSITION, SYSTEM, KIT AND USES THEREOF
  申请人：CNC - Centro de Neurociências e Biologia Molecular - Universidade de Coimbra

  公开号：EP2935567B1

  公开（公告）日：2019-01-30
• COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS
  申请人：Illustris Pharmaceuticals, Inc.

  公开号：EP3442488A1

  公开（公告）日：2019-02-20
• METHODS AND COMPOSITIONS FOR TOPICAL DELIVERY
  申请人：Illustris Pharmaceuticals, Inc.

  公开号：EP3694489A2

  公开（公告）日：2020-08-19
• METHODS FOR TREATING NEUROLOGICAL DISORDERS OR DAMAGE
  申请人：Tyers Mike

  公开号：US20090076019A1

  公开（公告）日：2009-03-19

  A clonogenic neurosphere assay is described that carries out high throughput screens (HTS) to identify potent and/or selective modulators of proliferation, differentiation and/or renewal of neural precursor cells, neural progenitor cells and/or self-renewing and multipotent neural stem cells (NSCs). Compositions comprising the identified modulators and methods of using the modulators and compositions, in particular to treat neurological disorders (e.g. brain or CNS cancer) or damage are also disclosed.