2-(2-methylpropanoylamino)-N-[4-(2,2,2-trifluoroethoxy)pyridin-3-yl]pyridine-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2-methylpropanoylamino)-N-[4-(2,2,2-trifluoroethoxy)pyridin-3-yl]pyridine-4-carboxamide
• 化学式: C₁₇H₁₇F₃N₄O₃
• 分子量: 382.34
• InChiKey: NGSGOYFKVYMHAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS GSK-3 INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDINE SUBSTITUÉS UTILES EN TANT QU'AGONISTES DE GSK-3
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2015069593A1

  公开（公告）日：2015-05-14

  The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, antagonists of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

  该披露通常涉及到I式化合物，包括它们的盐，以及使用这些化合物的组合物和方法。这些化合物是NR2B受体的配体，是其拮抗剂，可能对治疗中枢神经系统的各种疾病有用。
• SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS GSK-3 INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3066092A1

  公开（公告）日：2016-09-14
• Substituted Pyridine Derivatives Useful as GSK-3 Inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160289210A1

  公开（公告）日：2016-10-06

  The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, antagonists of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
• US9809573B2
  申请人：——

  公开号：US9809573B2

  公开（公告）日：2017-11-07