Tert-butyl 4-((4-bromo-2,6-dimethylphenyl)sulfonyl)piperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl 4-((4-bromo-2,6-dimethylphenyl)sulfonyl)piperazine-1-carboxylate
• 英文别名: tert-butyl 4-(4-bromo-2,6-dimethylphenyl)sulfonylpiperazine-1-carboxylate
• 化学式: C₁₇H₂₅BrN₂O₄S
• 分子量: 433.4
• InChiKey: KGGZKBSOILTWJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  75.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 3-indol substituted derivatives, pharmaceutical compositions and methods for use
  申请人：Pfizer Inc.

  公开号：US10544095B2

  公开（公告）日：2020-01-28

  A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I.

  提供了一种式 I 的化合物： 或其药学上可接受的对映体、盐或溶剂。本发明进一步涉及式 I 化合物作为 TDO2 抑制剂的用途。本发明还涉及式 I 化合物在治疗和/或预防癌症、神经退行性疾病（如帕金森病、阿尔茨海默病和亨廷顿病）、慢性病毒感染（如 HCV 和 HIV）、抑郁症和肥胖症方面的用途。本发明还涉及一种制造式 I 化合物的工艺。
• NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE
  申请人：Pfizer Inc.

  公开号：US20180222862A1

  公开（公告）日：2018-08-09

  A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I.