(β-Hydroxy-aethyl)-benzyl-dimethylammonium | 13186-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (β-Hydroxy-aethyl)-benzyl-dimethylammonium
• 英文别名: Ammonium, benzyldimethyl(2-hydroxyethyl)-；benzyl-(2-hydroxyethyl)-dimethylazanium
• CAS: 13186-75-9
• 化学式: C₁₁H₁₈NO
• 分子量: 180.27
• InChiKey: NEUNOKQNYOCZNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (β-Hydroxy-aethyl)-benzyl-dimethylammonium 、 3'-O-benzoyl-5-fluoro-2'-deoxyfluorouridin-5'-yl H-phosphonate 在 吡啶 、 氯磷酸二苯酯 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  New antiglioma zwitterionic pronucleotides with an FdUMP framework

  摘要：

  We have designed and synthesized new 5-fluoro-2'-deoxyuridine 5'-phosphate pronucleotides which can function as potential agents against the glioblastoma multiforme tumor. Their anti-malignant potency has been tested against T98G, U-118 MG, U-87 MG gliomas, HeLa, and Caco-2 cancer cell lines, using MRC-5 healthy cells as a reference. Five of the sixteen compounds (4c, 4f-i) exhibited significant anticancer potency and high selectivity indices (SI 12-66). It is likely that these zwitterionic pronucleotides may function in a similar manner to zwitterionic phospholipids, by inducing cell membrane charge disorder, making the cell permeable to bioactive agents. The most promising therapeutic pronucleotides 4c, 4f-h, have high intestinal-blood uptake potency (Caco-2 cell line), and may be considered as potential, orally administrated, anticancer drugs. (C) 2017 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2017.12.070

文献信息

• SYNTHESIZING PET TRACERS USING [F-18]SULFONYL FLUORIDE AS A SOURCE OF [F-18]FLUORIDE
  申请人：Zhou Dong

  公开号：US20170197912A1

  公开（公告）日：2017-07-13

  The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of PET radiopharmaceuticals.

  本公开涉及一种制备具有适用于高效放射标记的[F-18]磺酰氟形式的反应性[F-18]氟化物的方法，该方法无需通过阿泽特罗普蒸发步骤，而是通过使用阴离子交换树脂和磺酰氯，并且在PET放射性药物制造中的应用。
• FIRE RESISTANT GLAZINGS
  申请人：Varma Karikath Sukumar

  公开号：US20120263903A1

  公开（公告）日：2012-10-18

  An additive for alkali metal silicate solutions, comprising a quaternary ammonium compound having the general formula ( 1 ) R 1 R 2 R 3 R 4 N + OH − , wherein R 1 , R 2 , R 3 and R 4 which may be the same or different represent alkyl groups, hydroxy-substituted alkyl groups, alkaryl groups, hydroxy-substituted alkaryl groups comprising from 1 to 12 carbon atoms, or groups having the general formula —[CH 2 ]n-N + R 5 R 6 R 7 wherein n is an integer having a value of from 1 to 12, the group —[CH 2 ]n may be hydroxy-substituted, and R 5 , R 6 and R 7 which may be the same or different represent alkyl groups, hydroxy-substituted alkyl groups, alkaryl groups or hydroxy-substituted alkaryl groups comprising from 1 to 12 carbon atoms; with the proviso that at least one of the groups R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 represents a hydroxy-substituted alkyl group or a hydroxy-substituted alkaryl group comprising at least 2 carbon atoms wherein the hydroxy substituent is not located on a carbon atom which is bonded to a nitrogen atom.

  一种用于碱金属硅酸盐溶液的添加剂，包括具有一般式（1）R1R2R3R4N+OH−的季铵化合物，其中R1、R2、R3和R4（可以相同也可以不同）代表烷基基团、羟基取代的烷基基团、烷基芳基基团、羟基取代的烷基芳基基团，包括1至12个碳原子，或具有一般式—[CH2]n-N+R5R6R7，其中n为1至12的整数，基—[CH2]n可以是羟基取代的，R5、R6和R7（可以相同也可以不同）代表烷基基团、羟基取代的烷基基团、烷基芳基基团或羟基取代的烷基芳基基团，包括1至12个碳原子；但其中至少一个R1、R2、R3、R4、R5、R6和R7代表至少含有2个碳原子的羟基取代的烷基基团或羟基取代的烷基芳基基团，其中羟基取代物不位于与氮原子键合的碳原子上。
• [EN] PHOSPHONATE-CONTAINING CROSSLINKERS<br/>[FR] AGENTS DE RÉTICULATION CONTENANT DES PHOSPHONATES
  申请人：UNIV UTRECHT HOLDING BV

  公开号：WO2020060412A1

  公开（公告）日：2020-03-26

  Disclosed are phosphonate-containing trifunctional crosslinkers and methods for synthesizing same. The invention further pertains to using the trifunctional crosslinkers in methods for crosslinking, purifying, and characterizing biomolecules such as peptides, proteins and polynucleotides.

  揭示了含膦酸盐的三官能交联剂以及其合成方法。该发明还涉及在交联、纯化和表征肽、蛋白质和多核苷酸等生物分子的方法中使用这种三官能交联剂。
• PROCESS FOR PREPARING 5-HYDROXYMETHYLFURFURAL VIA 5-ACYLOXYMETHYLFURFURAL AS AN INTERMEDIATE
  申请人：Reichert Dietmar

  公开号：US20080200698A1

  公开（公告）日：2008-08-21

  5-hydroxymethylfurfural of the formula II is prepared via a 5-acyloxymethylfurfural as an intermediate.

  通过5-酰氧甲基糠醛作为中间体制备出式II的5-羟甲基糠醛。
• PREPARATION OF POLYISOCYANATES HAVING ISOCYANURATE GROUPS AND THEIR USE
  申请人：BASF SE

  公开号：US20130303758A1

  公开（公告）日：2013-11-14

  The present invention relates to a novel process for preparing polyisocyanates having isocyanurate groups by a partial trimerization of (cyclo)aliphatic diisocyanates in the presence of at least one trimerization catalyst from the group of ammonium salts of lactames and to the use of the thus obtainable polyisocyanates having isocyanurate groups as a polyisocyanate component in polyurethane coatings.

  本发明涉及一种新型的制备具有异氰酸酯基的聚异氰酸酯的方法，该方法通过在至少一种催化三聚反应的羧酸内酰胺铵盐存在下进行（环）脂肪族二异氰酸酯的部分三聚反应来实现，并且该得到的具有异氰酸酯基的聚异氰酸酯可用作聚氨酯涂料中的聚异氰酸酯组分。