Formparanate | 17702-57-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Formparanate
• 英文别名: [4-(dimethylaminomethylideneamino)-3-methylphenyl] N-methylcarbamate
• CAS: 17702-57-7
• 化学式: C₁₂H₁₇N₃O₂
• 分子量: 235.28
• InChiKey: NPCUJHYOBSHUJJ-UHFFFAOYSA-N

物化性质

• 沸点：
  377.68°C (rough estimate)
• 密度：
  1.1243 (rough estimate)
• 物理描述：
  Formparanate appears as a solid. (EPA, 1998)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.9
• 氢给体数：
  1
• 氢受体数：
  3

ADMET

毒理性

• 副作用

其他毒药 - 氨基甲酸酯

Other Poison - Carbamate

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 人类毒性摘录

症状学：除了强度和持续时间有所减少，尤其是中枢神经系统体征和症状外，氨基甲酸盐中毒的临床表现与对硫磷中毒相似。1. 恶心、呕吐、腹部绞痛、腹泻以及过度流涎（多涎症）和出汗。2. 疲乏和虚弱。3. 呼吸道暴露可能导致鼻涕和胸部紧缩感。4. 视力模糊或暗淡、瞳孔缩小（固定针尖样瞳孔）、流泪、睫状肌痉挛、调节能力丧失和眼痛。然而，这些眼科症状并不可靠用于诊断。由于交感肾上腺系统的放电，可能出现瞳孔散大。5. 肌肉协调性丧失、言语不清、肌肉颤动和抽搐。6. 呼吸困难、唾液和呼吸道粘液过度分泌、口鼻泡沫、发绀、肺啰音和哮鸣音以及高血压（可能是由于窒息）。7. 随机抽动、失禁、惊厥和昏迷。8. 死亡主要由于中枢性呼吸暂停、呼吸肌麻痹、剧烈支气管收缩或三者共同导致。/甲萘威/

Symptomatology: Except for diminished intensity and duration, particularly of the central nervous signs and symptoms, carbamate poisoning resembles parathion intoxication in its clinical manifestations. 1. Nausea, vomiting, abdominal cramps, diarrhea and excessive salivation (sialorrhea) and sweating. 2. Lassitude and weakness. 3. Rhinorrhea and a sensation of tightness in the chest may occur with respiratory exposures. 4. Blurring or dimness of vision, miosis (with fixed pinpoint pupils), tearing, ciliary muscle spasm, loss of accommodation and ocular pain. None of these eye signs, however, is dependable for diagnosis. Mydriasis may be seen secondary to sympathoadrenal discharge. 5. Loss of muscle coordination, slurring of speech, fasciculations and twitching of muscles. 6. Difficulty in breathing, excessive secretions of saliva and of respiratory tract mucus, oronasal frothing, cyanosis, pulmonary rales and rhonchi and hypertension (presumably due to asphyxia). 7. Random jerky movements, incontinence, convulsions and coma. 8. Death primarily due to respiratory arrest of central origin, paralysis of the respiratory muscles, intense bronchoconstriction or all three. /Carbaryl/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

快速可逆的胆碱酯酶抑制剂...在大鼠中，给予20毫克/千克/天的食物，持续90天，描述了肝脏和肾脏损伤（有些死亡）。/甲酸酯/

Rapidly reversible cholinesterase inhibitor ... Liver & kidney damage (with some deaths) was described in rats given 20 mg/kg daily in food for 90 days. /Formetanate/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)
• 包装等级：
  II
• 危险类别：
  6.1(a)

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• Novel insecticides
  申请人：Syngenta Participations AG

  公开号：EP2540718A1

  公开（公告）日：2013-01-02

  Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.

  式I的化合物 其中取代基如权利要求1所定义，并且式I化合物的农药可接受盐以及所有立体异构体和互变异构形式可用作杀虫剂，并且可以按照已知的方法制备。
• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。