P,P',P'',P'''-[1,4-亚苯基二次苄基]四苯酚 | 38050-97-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: P,P',P'',P'''-[1,4-亚苯基二次苄基]四苯酚
• 英文名称: 1,4-bis-(4',4"-dihydroxy-triphenyl-methyl)-benzene
• 英文别名: 1,4-Bis(alpha,alpha-bis(4-hydroxyphenyl)benzyl)benzene；4-[[4-[bis(4-hydroxyphenyl)-phenylmethyl]phenyl]-(4-hydroxyphenyl)-phenylmethyl]phenol
• CAS: 38050-97-4
• 化学式: C₄₄H₃₄O₄
• 分子量: 626.752
• InChiKey: UVHRMZIIPPMNSR-UHFFFAOYSA-N

物化性质

• 沸点：
  803.5±60.0 °C(Predicted)
• 密度：
  1.263±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  48
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2907199090

反应信息

• 作为产物：
  描述：

  1,4-Bis-(phenyldichlormethyl)-benzol 、 苯酚 以 1,4-二氧六环 为溶剂， 生成 P,P',P'',P'''-[1,4-亚苯基二次苄基]四苯酚
  参考文献：
  名称：

  Process for preparing geminal dihalides

  摘要：

  双卤代伽马位化合物是通过在有机磷化合物存在下，将非烯醇化醛和/或酮与光气或亚砜氯反应制备而成的。

  公开号：

  US04044060A1

文献信息

• Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
  申请人：Link T. James

  公开号：US20050245534A1

  公开（公告）日：2005-11-03

  The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.

  本发明涉及抑制11-β-羟基皮质酮脱氢酶1型酶的化合物。本发明还涉及利用11-β-羟基皮质酮脱氢酶1型酶抑制剂治疗非胰岛素依赖型2型糖尿病、胰岛素抵抗、肥胖、脂质紊乱、代谢综合征以及其他由过多糖皮质激素作用介导的疾病和病况。
• [EN] 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES<br/>[FR] DERIVES DE 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RENINE DANS LE TRAITEMENT DE L'HYPERTENSION, DE MALADIES CARDIOVASCULAIRES OU RENALES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003093267A1

  公开（公告）日：2003-11-13

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.

  该发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物（I）及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，尤其是它们作为肾素抑制剂的用途。
• PURIFICATION OF TRIS-HYDROXYARYL COMPOUNDS
  申请人：Münnich Christian

  公开号：US20110251438A1

  公开（公告）日：2011-10-13

  The present invention is directed to a composition comprising a tris-hydroxyaryl compound having a metal ion impurity content of less than 10 ppm and to a process for the purification of tris-hydroxyaryl compound having a metal ion impurity, comprising at least the following steps: a) conditioning a sulphonic acid group-containing active ion exchanger with a solvent which is suitable for the handling of the tris-hydroxyaryl compounds, b) producing a solution of the tris-hydroxyaryl compounds to be purified in a solvent which is suitable for the handling of the tris-hydroxyaryl compounds, c) contacting the tris-hydroxyaryl compound-containing solution from b) with the conditioned ion exchanger from a), d) separating the tris-hydroxyaryl compound-containing solution from c) from the conditioned ion exchanger, e) removing at least part of the solvent from the solution of the tris-hydroxyaryl compound separated in d) under low temperature stress.

  本发明涉及一种组合物，包括一种三羟基芳基化合物，其金属离子杂质含量低于10 ppm，以及用于纯化具有金属离子杂质的三羟基芳基化合物的方法，包括至少以下步骤：a)用适合处理三羟基芳基化合物的溶剂调节含有磺酸基团的活性离子交换剂，b)在适合处理三羟基芳基化合物的溶剂中制备待纯化的三羟基芳基化合物的溶液，c)将步骤b)中含有三羟基芳基化合物的溶液与步骤a)中的调节离子交换剂接触，d)将步骤c)中含有三羟基芳基化合物的溶液与调节离子交换剂分离，e)在低温应力下从步骤d)中分离的三羟基芳基化合物的溶液中至少去除部分溶剂。
• Process for producing an aromatic polycarbonate
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20030166826A1

  公开（公告）日：2003-09-04

  To produce an aromatic polycarbonate excellent in physical properties and hue by a simplified step as compared with a conventional one. A process for producing an aromatic polycarbonate, which comprises the following steps (1) to (3): (1) a step of reacting phenol with acetone in the presence of an acid catalyst to convert part of the phenol into bisphenol A, to obtain a bisphenol A/phenol composition, (2) a step of supplying the bisphenol A/phenol composition held in a molten state in a liquid form to an aromatic polycarbonate production step, and (3) a step of reacting the bisphenol A and a carbonate material to produce an aromatic polycarbonate.

  通过比传统方法简化步骤，生产出物理性能和色泽优异的芳香族聚碳酸酯。生产芳香族聚碳酸酯的方法包括以下步骤（1）至（3）：（1）在酸催化剂的存在下，将苯酚与丙酮反应，将部分苯酚转化为双酚A，获得双酚A/苯酚组成的混合物，（2）将保持熔化状态的双酚A/苯酚混合物以液态形式供给芳香族聚碳酸酯生产步骤，（3）将双酚A和碳酸酯材料反应，生产出芳香族聚碳酸酯。
• Polycarbonates, polyester carbonates and polyesters with special branched terminal groups
  申请人：——

  公开号：US20040030090A1

  公开（公告）日：2004-02-12

  A phenolic compound having a branched structure is disclosed. The compound conforms to HO—Ar 1 —X—Ar 2 —[Y—W] n ( 1 ) wherein Ar 1 and Ar 2 independently denote an optionally substituted mononuclear or polynuclear aromatic moiety, X and Y independently denote a single bond or a divalent radical, W denotes an optionally substituted mononuclear or polynuclear aromatic moiety or an aliphatic or cycloaliphatic radical, and n is 1 to 5, is useful as a terminal group in polycarbonates, polyester carbonates and polyesters. Also disclosed is a process for producing such resins where the disclosed compound is a chain terminator.

  本发明公开了一种具有支链结构的酚类化合物。该化合物符合HO—Ar1—X—Ar2—[Y—W]n(1)式，其中Ar1和Ar2分别表示可选取代的单核或多核芳香基团，X和Y独立地表示单键或双价基团，W表示可选取代的单核或多核芳香基团或脂肪族或环烷基团，n为1至5，可用作聚碳酸酯、聚酯碳酸酯和聚酯中的末端基团。本发明还公开了一种制备这种树脂的方法，其中所公开的化合物是链终止剂。