Bis-(p-aminophenyl)-carbonat | 19363-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis-(p-aminophenyl)-carbonat
• 英文别名: Bis(4-aminophenyl)carbonat；Bis-<4-amino-phenyl>-carbonat；Bis(4-aminophenyl) carbonate
• CAS: 19363-39-4
• 化学式: C₁₃H₁₂N₂O₃
• 分子量: 244.25
• InChiKey: JBBBDGJYVDMMMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(BOC-氨基)酚 在 盐酸 、 三乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 4.17h， 生成 Bis-(p-aminophenyl)-carbonat
  参考文献：
  名称：

  钯催化氢氨基羰基化聚合合成脂环族聚酰胺

  摘要：

  聚酰胺代表了现代社会中重要的一类材料。由于聚酰胺在各个领域的众多潜在应用，对新的聚酰胺结构的需求很高，这就需要开发新的聚合方法。在此，我们报道了一种新型高效的钯催化二烯和二胺的氢氨基羰基化聚合，用于合成脂环族聚酰胺。该方法采用容易获得的起始原料，以原子经济的方式进行，并以高产率和高分子量产生了一系列新型功能性聚酰胺。与传统的己二酸基聚酰胺相比，脂环族聚酰胺具有优异的耐热性、更高的玻璃化转变温度以及在常见有机溶剂中更好的溶解性，因此可能具有高性能和良好的加工性能的优点。

  DOI：

  10.1021/jacs.4c01210

文献信息

• [EN] PEPTIDE-DRUG CONJUGATES<br/>[FR] CONJUGUÉS PEPTIDE-MÉDICAMENT
  申请人：CHU SHAOSONG

  公开号：WO2015187540A1

  公开（公告）日：2015-12-10

  Peptide-drug conjugates comprising p-aminobenzyl carbamoyl or p-aminobenzolyl carbonate self-immolating linkers are disclosed. The peptide-drug conjugates comprise a peptide moiety that can be cleaved by cellular proteases, bound to the self-immolating linker, which linker is bound to a cytotoxic drug moiety. Upon cleavage of the peptide moiety, the linker self- immolates, releasing the cytotoxic drug in active form. Dimeric structures of the peptide drug conjugates comprising two molecules of cytotoxic drug per conjugate are also disclosed.

  肽-药物共轭物包括p-氨基苯甲酰基或p-氨基苯酰基碳酸酯自解链。这些肽-药物共轭物包括一个可以被细胞蛋白酶裂解的肽基团，与自解链结合，该链结合到一个细胞毒性药物基团。在肽基团被裂解后，链自解，释放活性形式的细胞毒性药物。还公开了包含每个共轭物中两分子细胞毒性药物的肽药物共轭物的二聚体结构。
• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Polymeric Coatings Incorporating Bioactive Enzymes for Catalytic Function
  申请人：McDaniel C. Steven

  公开号：US20120097194A1

  公开（公告）日：2012-04-26

  Disclosed herein are materials including a polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a coating, a textile finish or a wax; a filler for such a polymeric material or a surface treatment, which includes an enzyme such as an esterase (e.g., a lipolytic enzyme, an organophosphorus compound degradation enzyme), wherein the enzyme decontaminates a chemical from the surface of the material. Also disclosed herein are methods of cleaning a surface of a material that comprises an enzyme.

  本文公开了一种材料，包括聚合物材料，例如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；表面处理，例如涂层、纺织品处理或蜡；用于上述聚合物材料或表面处理的填料，其中包括酶，例如酯酶（例如脂肪水解酶、有机磷化合物降解酶），其中酶可从材料表面去除化学物质。本文还公开了一种清洁含有酶的材料表面的方法。
• Polymeric Coatings Incorporating Bioactive Enzymes for Cleaning a Surface
  申请人：Wales Melinda

  公开号：US20110240064A1

  公开（公告）日：2011-10-06

  Disclosed herein are a materials such as a coating, such as an architectural coating or a CARC coating, comprising a lipolytic enzyme or organophosphorous compound degrading enzyme. Also disclosed herein are methods of decontaminating a surface comprising such a material from a chemical substrate of an enzyme such as a lipid or an organophosphorus compound.

  本文公开了一种材料，例如涂层，如建筑涂层或CARC涂层，包括脂肪水解酶或有机磷化合物降解酶。本文还公开了一种从酶的化学底物，例如脂质或有机磷化合物，中去除此类材料表面的污染物的方法。
• Visual Assays for Coatings Incorporating Bioactive Enzymes for Catalytic Functions
  申请人：Williams Eric B.

  公开号：US20110250626A1

  公开（公告）日：2011-10-13

  Disclosed herein are materials such as a coating, comprising a lipolytic enzyme or organophosphrous compound degrading enzyme. Also disclosed herein are methods of visually detecting enzyme activity in a coating by contacting the coating with a substrate of an enzyme and a visual indicator that changes appearance upon production of a product of enzyme activity on a tack-free coating surface.

  本文公开了一种涂层材料，包括脂肪水解酶或有机磷化合物降解酶。本文还公开了一种方法，通过将涂层与酶底物和视觉指示剂接触，以在无粘涂层表面产生酶活性产物时改变外观来检测酶活性的方法。