6-chloro-5-(2-(6-(4-cyclopropyl-2-fluorophenyl)-3,4,8,9-tetrahydro-1H-pyrido[4’,3’:4,5]imidazo[2,1-c][1,4]oxazin-7(6H)-yl)-2-oxoethoxy)-N,N-dimethylpicolinamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-chloro-5-(2-(6-(4-cyclopropyl-2-fluorophenyl)-3,4,8,9-tetrahydro-1H-pyrido[4’,3’:4,5]imidazo[2,1-c][1,4]oxazin-7(6H)-yl)-2-oxoethoxy)-N,N-dimethylpicolinamide
• 英文别名: 6-chloro-5-[2-[3-(4-cyclopropyl-2-fluorophenyl)-11-oxa-1,4,8-triazatricyclo[7.4.0.02,7]trideca-2(7),8-dien-4-yl]-2-oxoethoxy]-N,N-dimethylpyridine-2-carboxamide
• 化学式: C₂₈H₂₉ClFN₅O₄
• 分子量: 554.021
• InChiKey: VNVYQQUIGBABBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  89.8
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Tricyclic imidazole compounds as inhibitors of tryptophan hydroxylase
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US10189839B2

  公开（公告）日：2019-01-29

  The present invention relates to compounds of the formula (I) wherein R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

  本发明涉及式 (I) 的化合物 其中 R1a、R1b、R2、R3 和 X 如描述中所述，涉及它们的制备，涉及它们的药学上可接受的盐，涉及它们作为药物的用途，涉及含有一种或多种式（I）化合物的药物组合物，涉及这种式（I）化合物的制备方法，尤其涉及它们作为 TPH 调节剂的用途。
• TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE
  申请人：Actelion Pharmaceuticals Ltd

  公开号：EP3071567B1

  公开（公告）日：2017-09-06