ACETAMIDE, 2-(o-TOLYLTHIO)- | 32175-45-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: ACETAMIDE, 2-(o-TOLYLTHIO)-
• 英文别名: 2-(2-methylphenyl)sulfanylacetamide
• CAS: 32175-45-4
• 化学式: C₉H₁₁NOS
• mdl: MFCD01671214
• 分子量: 181.26
• InChiKey: ZDADERXOZWLKDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF
  申请人：Sugasawa Keizo

  公开号：US20100249088A1

  公开（公告）日：2010-09-30

  [Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, based on an excellent trkA receptor inhibitory action. [Means for Solution] A novel azolecarboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof is confirmed to have a potent trkA receptor inhibitory activity, and found to be capable of being used as a therapeutic and/or prophylactic agent which is excellent in efficacy and safety for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, thereby completing the present invention.

  [目的] 提供一种治疗和/或预防下尿道疾病引起的尿频、尿急和尿失禁的治疗剂和/或预防剂，包括膀胱过度活动、伴有下尿道疼痛的各种下尿道疾病，如间质性膀胱炎、慢性前列腺炎等，以及伴有疼痛的各种疾病，基于出色的trkA受体抑制作用。 [解决方案] 发现一种新型的唑类羧酰胺化合物，其中一种噻唑环或噁唑环通过羧酰胺键与苯环、吡啶环、吡嗪环、噻吩环、吡唑环或吡咯环结合，或其盐具有强效的trkA受体抑制活性，并发现它能够被用作治疗和/或预防剂，对于包括膀胱过度活动、伴有下尿道疼痛的各种下尿道疾病，如间质性膀胱炎、慢性前列腺炎等，以及伴有疼痛的各种疾病，具有出色的疗效和安全性，从而完成了本发明。
• US4144391A
  申请人：——

  公开号：US4144391A

  公开（公告）日：1979-03-13
• US4329454A
  申请人：——

  公开号：US4329454A

  公开（公告）日：1982-05-11
• US8304547B2
  申请人：——

  公开号：US8304547B2

  公开（公告）日：2012-11-06