α-<(2-Hydroxy-1-methyl-3,3,3-trifluor-2-trifluormethyl)-propyl>benzylalkohol | 34844-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-<(2-Hydroxy-1-methyl-3,3,3-trifluor-2-trifluormethyl)-propyl>benzylalkohol
• 英文别名: 1,3-Butanediol, 2-methyl-1-phenyl-4,4,4-trifluoro-3-trifluoromethyl-；4,4,4-trifluoro-2-methyl-1-phenyl-3-(trifluoromethyl)butane-1,3-diol
• CAS: 34844-08-1
• 化学式: C₁₂H₁₂F₆O₂
• 分子量: 302.216
• InChiKey: USWUWAGJWLNXBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Processes for producing fluorine-containing 2,4-diols and their derivatives
  申请人：Komata Takeo

  公开号：US20050215836A1

  公开（公告）日：2005-09-29

  A process for producing a fluorine-containing 2,4-diol represented by the formula [4], wherein R 1 represents a hydrogen atom or an acyclic or cyclic alkyl group having a carbon atom number of 1 to 7; R 2 represents an acyclic or cyclic alkyl group having a carbon atom number of 1 to 7, a phenyl group, or a substituted phenyl group; and R 1 and R 2 are optionally bonded to each other to form a ring, includes reducing a hydroxy ketone represented by the formula [3], wherein R 1 and R 2 are defined as above, by hydrogen in the presence of a ruthenium catalyst.

  生产一种由下式表示的含氟2,4-二醇的方法， 其中R1代表氢原子或具有1至7个碳原子的非环状或环状烷基基团；R2代表具有1至7个碳原子的非环状或环状烷基基团、苯基或取代苯基；且R1和R2可以选择地相互连接以形成环，包括在钌催化剂存在下用氢还原由下式表示的羟基酮， 其中R1和R2如上定义。
• Process for producing fluorine-containing diol and its derivatives
  申请人：Komata Takeo

  公开号：US20070032684A1

  公开（公告）日：2007-02-08

  A process for producing a fluorine-containing diol represented by the formula [2], includes reducing a hydroxy ketone represented by the formula [1], by hydrogen in the presence of a ruthenium catalyst. The ruthenium catalyst may be a solid-phase catalyst in which ruthenium is carried on an activated carbon, alumina or silica.

  一种制备含氟二元醇的方法，其化学式为[2]，包括在钌催化剂的存在下，通过氢气还原化学式为[1]的羟基酮。钌催化剂可以是固相催化剂，其中钌负载在活性炭、氧化铝或二氧化硅上。
• Process for producing alpha-substituted acrylic acid esters
  申请人：Komata Takeo

  公开号：US20050165249A1

  公开（公告）日：2005-07-28

  A process for producing an α-substituted acrylic acid ester represented by the formula [1], wherein each of R 1 and R 2 is independently a hydrogen atom, methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, sec-butyl group, tert-butyl group, fluoromethyl group, difluoromethyl group, trifluoromethyl group, or perfluoroethyl group, includes reacting an α-substituted acrylic acid anhydride represented by the formula [7], with 1,1-bis(trifluoromethyl)-1,3-diol represented by the formula [2].

  生产α-取代丙烯酸酯的方法，其化学式为[1]，其中R1和R2分别独立地为氢原子、甲基、乙基、n-丙基、异丙基、n-丁基、sec-丁基、tert-丁基、氟甲基、二氟甲基、三氟甲基或全氟乙基，包括将化学式为[7]的α-取代丙烯酸酐与化学式为[2]的1,1-双(三氟甲基)-1,3-二醇反应。
• US7067691B2
  申请人：——

  公开号：US7067691B2

  公开（公告）日：2006-06-27
• US7205443B2
  申请人：——

  公开号：US7205443B2

  公开（公告）日：2007-04-17