Methyl 3-ethyl-2-fluorobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3-ethyl-2-fluorobenzoate
• 英文别名: methyl 3-ethyl-2-fluorobenzoate
• 化学式: C₁₀H₁₁FO₂
• 分子量: 182.19
• InChiKey: VZTNGYAGBQJEDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE DIHYDROFUROPYRIDINE EN TANT QU'INHIBITEURS DE LA RHO-KINASE
  申请人：[en]CHIESI FARMACEUTICI S.P.A.

  公开号：WO2022128843A1

  公开（公告）日：2022-06-23

  The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).