1-Methyl-2-phenylpyridinium | 52806-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Methyl-2-phenylpyridinium
• 英文别名: 1-methyl-2-phenylpyridin-1-ium
• CAS: 52806-03-8
• 化学式: C12H12N+
• 分子量: 170.23
• InChiKey: ZLNAOQQGJXUMPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• 7,8-BICYCLOAKYL-CHROMAN DERIVATIVES
  申请人：Wang Bing

  公开号：US20090170814A1

  公开（公告）日：2009-07-02

  7,8-Bicyclic-chroman derivatives of Formula I: wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for the treatment of inflammatory disorders, neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

  公式I的7,8-双环色基衍生物，其中取代基如规范中定义或其药学上可接受的盐被揭示。它们可用于治疗炎症性疾病、神经退行性疾病和/或线粒体疾病。它们还可用于制造用于治疗这些疾病的药物制剂。
• Polymer engineered regenerating bioscavengers
  申请人：Carnegie Mellon University

  公开号：US10400232B2

  公开（公告）日：2019-09-03

  Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime functional groups.

  本发明的实施例提供了至少一种与酯酶共价连接的聚合物。至少一种聚合物包括多个肟官能团。
• Synergistic liposomal formulation for the treatment of cancer
  申请人：Council of Scientific and Industrial Research

  公开号：US10426728B2

  公开（公告）日：2019-10-01

  The present disclosure relates to the synergistic liposomal formulation comprising, phophatidylcholine, stearylamine and anticancer drugs for the treatment of cancer. The PC:SA cationic liposome encapsulated camptothecin (CPT) and doxorubicin (DOX) formulations show enhanced synergistic anti-cancer effect and provide improved therapeutic index as compared to either the liposome or drug alone. The present disclosure also relates to the use of Cationic liposomal preparation of phosphatidylcholine:stearylamine (PC:SA) showing anticancer effect. The SA-bearing liposome and drug entrapped in the liposome are effective against cancer both in vitro and in vivo, without causing any adverse effect on host.

  本公开涉及用于治疗癌症的由磷脂酰胆碱、硬脂胺和抗癌药物组成的协同脂质体制剂。PC:SA 阳离子脂质体包裹的喜树碱（CPT）和多柔比星（DOX）制剂与单独的脂质体或药物相比，显示出更强的协同抗癌效果，并提供更好的治疗指数。本公开还涉及磷脂酰胆碱：硬脂酰氨基（PC:SA）阳离子脂质体制剂的抗癌作用。含 SA 的脂质体和脂质体中夹带的药物在体外和体内都能有效抗癌，且不会对宿主造成任何不良影响。
• FLUORESCENT GLYCOSIDES AND METHODS FOR THEIR USE
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20040215012A1

  公开（公告）日：2004-10-28

  Fluorescent glycosides containing aromatic hydrocarbon groups are useful in labelling and detection methods for a wide array of chemical and biological molecules. Assembly of multiple analogs to form “polyfluors” affords fluorescence properties that are different from the properties of the component analogs. This allows for the design and use of combinatorial libraries of molecules displaying widely varying fluorescence colors.

  含有芳香烃基团的荧光苷可用于多种化学和生物分子的标记和检测方法。将多种类似物组装成 "多荧光体"，可产生不同于各类似物的荧光特性。这样，就可以设计和使用显示不同荧光颜色的分子组合库。
• SYNERGISTIC LIPOSOMAL FORMULATION FOR THE TREATMENT OF CANCER
  申请人：Council of Scientific and Industrial Research

  公开号：EP3046542A1

  公开（公告）日：2016-07-27