(5E)-5-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-3-phenyl-2-thioxo-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5E)-5-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-3-phenyl-2-thioxo-1,3-thiazolidin-4-one
• 英文别名: (5E)-5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C20H12N2O4S2
• 分子量: 408.5
• InChiKey: CPJFRURCYGWNRT-LDADJPATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  137
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS<br/>[FR] COMPOSITIONS DE RHODANINE UTILISABLES COMME AGENTS ANTIVIRAUX
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2005041951A2

  公开（公告）日：2005-05-12

  This invention describes compounds and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In particular, the compounds and compositions are useful for treating diseases caused by viruses such as poxviruses and retroviruses. The invention further provides for methods of treating smallpox, Herpes virus and HIV infection in patients using the compounds and compositions of the invention.