(4-azaniumylphenyl)azanium;oxalate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-azaniumylphenyl)azanium;oxalate
• 化学式: C8H10N2O4
• 分子量: 198.18
• InChiKey: JBLFIYDHGYMNEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.01
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  6

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。 高铁血红蛋白血症 - 血液中高铁血红蛋白含量增加；该化合物被归类为第二毒性效应 皮肤致敏剂 - 能诱导皮肤过敏反应的制剂。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

对于立即急救：确保已经进行了充分的中和。如果受害者停止呼吸，请开始人工呼吸，最好使用受过培训的求阀复苏器、袋阀面罩装置或口袋面罩。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者向前倾或将其置于左侧（如果可能，头部向下）以保持呼吸道畅通，防止吸入。保持受害者安静，维持正常体温。获得医疗救助。/有机碱、胺类及相关化合物/

For immediate first aid: Ensure that adequate decontamination has been carried out. If victim is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Obtain medical attention. /Organic bases, amines, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……监测休克，如有必要，进行治疗……预见并治疗癫痫发作……眼睛污染时，立即用清水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……不要使用催吐剂。对于摄入，如果患者能吞咽，有强烈的呕吐反射，且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭……在去污染后，用无菌敷料覆盖皮肤烧伤……/有机碱、胺类及相关化合物/

For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... Monitor for shock and treat if necessary ... Anticipate seizures and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... Cover skin burns with sterile dressings after decontamination ... . /Organic bases, amines, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

/SRP/: 可能形成高铁血红蛋白的物质。

/SRP/: POTENTIAL METHEMOGLOBIN FORMER.

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• Rubber vulcanizates having improved ageing properties
  申请人：——

  公开号：US20010031836A1

  公开（公告）日：2001-10-18

  The invention relates to a vulcanizable rubber composition comprising a rubber, sulfur or a sulfur donor, a vulcanization accelerator, a protective agent and 0.1 phr or more of an N,N′-disubstituted p-phenylenediamine protective agent is present in the form of a salt with an acid, and the composition does not comprise an elastomeric copolymer having glycidyl groups. The invention also relates to a vulcanization process comprising mixing and heating said rubber composition and to an article of manufacture comprising the rubber vulcanizate obtained by said process. Preferably, the acid is a C 1 -C 24 monocarboxylic acid or a C 2 -C 24 dicarboxylic acid, more preferably a C 12 -C 20 fatty acid such as stearic acid. Most preferably, the protective agent is 6PPD.

  本发明涉及一种可硫化橡胶组合物，该组合物包含橡胶、硫磺或硫磺供体、硫化促进剂、保护剂和 0.1 phr 或更多的 N,N′-二取代对苯二胺保护剂，保护剂以酸盐形式存在，且该组合物不包含具有缩水甘油基团的弹性共聚物。本发明还涉及一种硫化工艺，包括混合和加热所述橡胶组合物，并涉及一种由通过所述工艺获得的橡胶硫化胶组成的制造品。酸最好是 C 1 -C 24 单羧酸或 C 2 -C 24 二羧酸，更优选 C 12 -C 20 脂肪酸，如硬脂酸。最优选的保护剂是 6PPD。
• Reduction of biological activity in water by feeding a solution of BrCl
  申请人：ALBEMARLE CORPORATION

  公开号：EP0518119B1

  公开（公告）日：1996-07-17
• RUBBER VULCANIZATES HAVING IMPROVED AGEING PROPERTIES
  申请人：Flexsys B.V.

  公开号：EP1263861A1

  公开（公告）日：2002-12-11
• A CHLORINE ANALYTICAL TEST ELEMENT AND A STABILIZED N,N-DIETHYL-P-PHENYLENEDIAMINE SOLUTION
  申请人：Hach Company

  公开号：EP3036541A1

  公开（公告）日：2016-06-29
• ELECTROCHEMICAL RECOGNITION AND QUANTIFICATION OF CYTOCHROME C OXIDASE EXPRESSION IN BACTERIA
  申请人：Oxford University Innovation Limited

  公开号：EP3682019A1

  公开（公告）日：2020-07-22