N-(4-hydroxyphenyl)-2-methanesulfonylacetamide | 64856-25-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-hydroxyphenyl)-2-methanesulfonylacetamide
• 英文别名: N-(4-hydroxyphenyl)-2-methylsulfonylacetamide
• CAS: 64856-25-3
• 化学式: C₉H₁₁NO₄S
• 分子量: 229.257
• InChiKey: PRAJYTGOSCUYMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(4-benzyloxy-phenyl)-2-methanesulfonyl-acetamide 、 N-(4-hydroxyphenyl)picolinamide 在 silica gel 、 甲醇 、 二氯甲烷 作用下， 以to give the product, 3.45 g (92%) as a colorless solid的产率得到N-(4-hydroxyphenyl)-2-methanesulfonylacetamide
  参考文献：
  名称：

  Hetero-Substituted Acetanilide Derivatives As Analgesic Agents

  摘要：

  本发明揭示了杂代替乙酰苯胺衍生物作为镇痛剂。本发明的化合物适用于治疗哺乳动物中由疼痛和/或发热所特征的疾病或症状的方法。

  公开号：

  US20150209339A1

文献信息

• [EN] HETERO-SUBSTITUTED ACETANILIDE DERIVATES AS ANALGESIC AGENTS<br/>[FR] ANALGESIQUES A BASE DE DERIVES ACETANILIDES HETERO-SUBSTITUES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005084663A1

  公开（公告）日：2005-09-15

  Hetero-substituted acetanil¡de derivatives are disclosed as analgesic agents. The compounds of the invention are useful in methods for treating a disease or condition in a mammal characterized by pain and/or fever.

  杂取代乙酰苯胺衍生物被披露为镇痛剂。本发明的化合物在治疗哺乳动物中由疼痛和/或发热特征的疾病或症状的方法中是有用的。
• HETERO-SUBSTITUTED ACETANILIDE DERIVATIVES AS ANALGESIC AGENTS
  申请人：Carson John R.

  公开号：US20100204284A1

  公开（公告）日：2010-08-12

  Hetero-substituted acetanilide derivatives are disclosed as analgesic agents. The compounds of the invention are useful in methods for treating a disease or condition in a mammal characterized by pain and/or fever.

  本发明揭示了杂代替醋酰苯胺衍生物作为镇痛剂。该发明的化合物在治疗哺乳动物的疾病或状况中具有用途，其特征为疼痛和/或发热。
• Hetero-Substituted Acetanilide Derivatives As Analgesic Agents
  申请人：Janssen Pharmaceutica N.V

  公开号：US20150209339A1

  公开（公告）日：2015-07-30

  Hetero-substituted acetanilide derivatives are disclosed as analgesic agents. The compounds of the invention are useful in methods for treating a disease or condition in a mammal characterized by pain and/or fever.

  本发明揭示了杂代替乙酰苯胺衍生物作为镇痛剂。本发明的化合物适用于治疗哺乳动物中由疼痛和/或发热所特征的疾病或症状的方法。
• COMPOSITIONS AND METHODS FOR TREATING PAIN AND/OR INFLAMMATION
  申请人：Neumentum, Inc.

  公开号：US20220008390A1

  公开（公告）日：2022-01-13

  Disclosed in certain embodiments is a method for treating chronic pain with a hetero-substituted acetanilide compound that modulates the adenosine receptor. Disclosed in certain embodiments is a method for treating neuropathic pain (e.g., acute or chronic) with a hetero-substituted acetanilide compound that modulates the adenosine A3 receptor. Disclosed in certain embodiments is a method for treating inflammation (e.g., local inflammation or systemic inflammation), an inflammatory response, or an inflammatory condition with a hetero-substituted acetanilide compound.
• US7718692B2
  申请人：——

  公开号：US7718692B2

  公开（公告）日：2010-05-18