Ro8-4304盐酸盐 | 1312991-77-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: Ro8-4304盐酸盐
• 英文名称: Ro 8-4304 Hydrochloride
• 英文别名: 4-[3-[4-(4-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-hydroxypropoxy]benzamide;hydrochloride
• CAS: 1312991-77-7
• 化学式: C21H24ClFN2O3
• 分子量: 406.9
• InChiKey: MQOXWHKUQOFFJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.88
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  75.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Methods and compositions for the treatment of alzheimer
  申请人：Universidad del Pais Vasco

  公开号：EP2338492A1

  公开（公告）日：2011-06-29

  The invention relates to AMPA receptor inhibitors and NMDA receptor inhibitors for use in the treatment of a disease associated with deposition of amyloid proteins, more precisely, Alzheimer.

  本发明涉及 AMPA 受体抑制剂和 NMDA 受体抑制剂，用于治疗与淀粉样蛋白沉积有关的疾病，更确切地说，是阿尔茨海默病。
• A DRUG SCREENING PLATFORM FOR RETT SYNDROME
  申请人：The Regents of the University of California

  公开号：EP2841067A2

  公开（公告）日：2015-03-04
• DRUG SCREENING PLATFORM FOR RETT SYNDROME
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150119327A1

  公开（公告）日：2015-04-30

  The invention provides a method for restoring a neural cell having a deficiency or alteration in glutamatergic pathway affecting neuron and/or glial function comprising contacting the cell with a NMDA receptor antagonist(s) and/or modulator(s) of a glutamatergic pathway, thereby restoring the neural cell having a deficiency or alteration in glutamatergic pathways affecting neuron and/or glial function.
• [EN] A DRUG SCREENING PLATFORM FOR RETT SYNDROME<br/>[FR] PLATE-FORME DE CRIBLAGE DE MÉDICAMENTS POUR LE SYNDROME DE RETT
  申请人：UNIV CALIFORNIA

  公开号：WO2013163455A2

  公开（公告）日：2013-10-31