4-[(E)-3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxoprop-1-enyl]-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 4-[(E)-3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxoprop-1-enyl]-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid
• 化学式: C₂₇H₂₂O₁₂
• 分子量: 538.5
• InChiKey: UJZQBMQZMKFSRV-XBXARRHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  211
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• Antiviral compositions and methods of use
  申请人：Johns Hopkins University

  公开号：US20020151584A1

  公开（公告）日：2002-10-17

  Purified antiviral compounds, pharmaceutical formulations containing the compounds, and methods of use of the compounds are provided. The compositions of the invention are isolated antiviral components from plant extracts derived from, for example, Salvia miltiorrhiza , that find use in the treatment of viral infections, such as by inhibiting the activity of viral integrase. Methods for isolation and purification of the antiviral compounds are additionally provided.

  本发明提供了纯化的抗病毒化合物、含有该化合物的药物制剂以及该化合物的使用方法。本发明的组合物是从例如以下植物提取物中分离出的抗病毒成分、 丹参 ，可用于治疗病毒感染，例如通过抑制病毒整合酶的活性。此外，还提供了抗病毒化合物的分离和纯化方法。
• A MULTI-COMPONENT INJECTION
  申请人：TIANJIN CHASE SUN PHARMACEUTICAL CO., LTD.

  公开号：US20190269609A1

  公开（公告）日：2019-09-05

  The invention relates to the technical field of medicines, and particularly relates to a multi-component injection and preparation processes and applications thereof. In the present invention, the effective ingredients of safflower carthamus. Red Paeony Root, Ligusticum wallichii , radix salviae miltiorrhizae and Angelica sinensis are analyzed and a multi-component injection is prepared via the modern pharmaceutical preparation technology. The study proves that the multi-component injection of the invention has therapeutic effects on Sepsis.
• US7071227B2
  申请人：——

  公开号：US7071227B2

  公开（公告）日：2006-07-04
• [EN] ANTIVIRAL COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS ANTIVIRALES ET LEURS PROCEDES D'UTILISATION
  申请人：——

  公开号：WO2002026726A9

  公开（公告）日：2003-03-20

  [EN] Purified antiviral compounds, pharmaceutical formulations containing the compounds, and methods of use of the compounds are provided. The compositions of the invention are isolated antiviral components from plant extracts derived from, for example, Salvia milriorrhiza, that find use in the treatment of viral infections, such as by inhibiting the activity of viral integrase. Methods for isolation and purification of the antiviral compounds are additionally provided.
  [FR] L'invention concerne des composés antiviraux, des formulations pharmaceutiques contenant ces composés, et des procédés d'utilisation de ces composés. Les compositions selon l'invention sont des composants antiviraux isolés, obtenus à partir d'extraits végétaux dérivés de, par exemple, Salvia miltiorrhiza, qui peuvent être utilisés dans le traitement d'infections virales, par exemple pour inhiber l'activité de l'intégrase virale. L'invention concerne également des procédés d'isolement et de purification des composés antiviraux.